Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Programmed Death-1 (PD-1; CD279) is an inhibitory receptor induced in activated T cells.
PD-1 engagement by its ligands, PD-L1 and PD-L2, maintains peripheral tolerance but also …

Diabetes mellitus type II and obesity are two important causes of death in modern society.
They are characterized by low-grade chronic inflammation and metabolic dysfunction (meta …

Adipose tissue macrophage (ATM) inflammation is involved with meta-inflammation and
pathology of metabolic complications. Here we report that in adipocytes, elevated lactate …

Metabolic disorders, such as obesity, type 2 diabetes mellitus, and nonalcoholic fatty liver
disease, are characterized by chronic low-grade tissue and systemic inflammation. During …

Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …

Metabolism, including glycolysis, oxidative phosphorylation, fatty acid oxidation, and other
metabolic pathways, impacts the phenotypes and functions of immune cells. The metabolic …

The present study aims to provide a narrative review of the molecular mechanisms of
Western diet-induced obesity and obesity-related carcinogenesis. A literature search of the …

Cellular senescence is a cell fate that occurs in response to numerous types of stress and
can promote tissue repair or drive inflammation and disruption of tissue homeostasis …

The COVID-19 pandemic has emerged as a public health crisis and has placed a significant
burden on healthcare systems. Patients with underlying metabolic dysfunction, such as type …