Although RAS was formerly considered undruggable, various agents that inhibit RAS or
specific RAS oncoproteins have now been developed. Indeed, the importance of directly …

RAF family protein kinases are a key node in the RAS/RAF/MAP kinase pathway, the
signaling cascade that controls cellular proliferation, differentiation, and survival in response …

Tumor cells evade targeted drugs by rewiring their genetic and epigenetic networks. Here,
we identified that inhibition of MAPK signaling rapidly induces an epithelial-to-mesenchymal …

RAS–MAPK signalling is fundamental for cell proliferation and is altered in most human
cancers,–. However, our mechanistic understanding of how RAS signals through RAF is still …

RAF-family kinases are activated by recruitment to the plasma membrane by GTP-bound
RAS, whereupon they initiate signaling through the MAP kinase cascade. Prior structural …

The architectures of tandem-repeat proteins are distinct from those of globular proteins.
Individual modules, each comprising small structural motifs of 20–40 residues, are arrayed …

Abstract KRAS G12C mutations in non-small cell lung cancer (NSCLC) partially respond to
KRAS G12C covalent inhibitors. However, early adaptive resistance occurs due to rewiring …

Mutations in the RAS–RAF–MEK–ERK pathway are frequent alterations in cancer and
RASopathies, and while RAS oncogene activation alone affects 19% of all patients and …

PR65 is the HEAT repeat scaffold subunit of the heterotrimeric protein phosphatase 2A
(PP2A) and an archetypal tandem repeat protein. Its conformational mechanics plays a …

Mutations in RAS proteins play a pivotal role in the development of human cancers, driving
persistent RAF activation and deregulating the mitogen-activated protein kinase (MAPK) …