Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …

Since the beautiful images of Santiago Ramón y Cajal provided a first glimpse into the
immense diversity and complexity of cell types found in the cerebral cortex, neuroscience …

In multicellular lives, the differentiation of stem cells and progenitor cells is often
accompanied by a transition from glycolysis to mitochondrial oxidative phosphorylation …

During the intricate process by which cells give rise to tissues, embryonic and adult stem
cells are exposed to diverse mechanical signals from the extracellular matrix (ECM) that …

Aging changes the mechanical properties of brain tissue, such as stiffness. It has been
proposed that the maintenance and differentiation of neural stem cells (NSCs) are regulated …

The emerging technology of brain organoids deriving from human pluripotent stem cells
provides unprecedented opportunities to study human brain development and associated …

Background The brain is a highly mechanosensitive organ, and changes in the mechanical
properties of brain tissue influence many physiological and pathological processes. Piezo …

The extracellular matrix (ECM) is a dynamic and complex network of proteins and molecules
that surrounds cells and tissues in the nervous system and orchestrates a myriad of …

Functional output of the hippocampus, a brain region subserving memory function, depends
on highly orchestrated cellular and molecular processes that regulate synaptic plasticity …

Brain organoids are invaluable tools for pathophysiological studies or drug screening, but
there are still challenges to overcome in making them more reproducible and relevant …