Cerebral iron deposition in neurodegeneration

P Dusek, T Hofer, J Alexander, PM Roos, JO Aaseth - Biomolecules, 2022 - mdpi.com
Disruption of cerebral iron regulation appears to have a role in aging and in the
pathogenesis of various neurodegenerative disorders. Possible unfavorable impacts of iron …

Senescent microglia: the key to the ageing brain?

EK Greenwood, DR Brown - International Journal of Molecular Sciences, 2021 - mdpi.com
Ageing represents the single biggest risk factor for development of neurodegenerative
disease. Despite being such long-lived cells, microglia have been relatively understudied for …

Iron overload induces cerebral endothelial senescence in aged mice and in primary culture in a sex‐dependent manner

B Noh, MP Blasco‐Conesa, SM Rahman, S Monga… - Aging …, 2023 - Wiley Online Library
Iron imbalance in the brain negatively affects brain function. With aging, iron levels increase
in the brain and contribute to brain damage and neurological disorders. Changes in the …

Can nutrients and dietary supplements potentially improve cognitive performance also in esports?

M Szot, E Karpęcka-Gałka, R Dróżdż, B Frączek - Healthcare, 2022 - mdpi.com
Factors influencing brain function and cognitive performance can be critical to athletic
performance of esports athletes. This review aims to discuss the potential beneficial effects …

Revisiting the role of vitamins and minerals in Alzheimer's disease

H Shah, F Dehghani, M Ramezan, RB Gannaban… - Antioxidants, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common type of dementia that affects millions of
individuals worldwide. It is an irreversible neurodegenerative disorder that is characterized …

Iron-overload-induced ferroptosis in mouse cerebral toxoplasmosis promotes brain injury and could be inhibited by Deferiprone

C Wang, L Xie, Y Xing, M Liu, J Yang… - PLOS Neglected …, 2023 - journals.plos.org
Iron is a trace metal element that is essential for the survival of cells and parasites. The role
of iron in cerebral toxoplasmosis (CT) is still unclear. Deferiprone (DFP) is the orally active …

Iron chelators as a therapeutic option for Alzheimer's disease—A mini-review

OD Schreiner, TG Schreiner - Frontiers in Aging, 2023 - frontiersin.org
Neurodegenerative disorders, particularly Alzheimer's disease (AD), remain a great
challenge regarding the finding of effective treatment, one main reason being the incomplete …

Association between serum iron concentrations and cognitive impairment in older adults aged 60 years and older: A dose-response analysis of National Health and …

Z Gong, W Song, M Gu, X Zhou, C Tian - PloS one, 2021 - journals.plos.org
Epidemiological evidence on peripheral iron and cognitive impairment in older adults is
sparse and limited. Results on serum iron and cognitive impairment in older adults from the …

Longitudinal differences in iron deposition in periaqueductal gray matter and anterior cingulate cortex are associated with response to erenumab in migraine

S Nikolova, CD Chong, GM Dumkrieger, J Li… - …, 2023 - journals.sagepub.com
Objectives The objective of this longitudinal study was to determine whether brain iron
accumulation, measured using magnetic resonance imaging magnetic transverse relaxation …

Alterations in iron content, iron-regulatory proteins and behaviour without tau pathology at one year following repetitive mild traumatic brain injury

SMA Juan, M Daglas, PH Truong, C Mawal… - Acta Neuropathologica …, 2023 - Springer
Repetitive mild traumatic brain injury (r-mTBI) has increasingly become recognised as a risk
factor for the development of neurodegenerative diseases, many of which are characterised …