Background Stimulant drugs are second only to cannabis as the most widely used class of
illicit drug globally, accounting for 68 million past-year consumers. Dependence on …

Rationale Agonist-based pharmacologic intervention is an accepted approach in treatment
of opioid and tobacco use disorders. Objectives We conducted a systematic review and …

Methamphetamine (MA) is a highly addictive psychostimulant drug that principally affects the
monoamine neurotransmitter systems of the brain and results in feelings of alertness …

Importance There are no medications approved by authorities for the treatment of
amphetamine or methamphetamine dependence, and studies investigating the …

Dopamine (DA) plays a well recognized role in a variety of physiologic functions such as
movement, cognition, mood, and reward. Consequently, many human disorders are due, in …

Methamphetamine dependence is a serious worldwide public health problem with major
medical, psychiatric, socioeconomic and legal consequences. Various neuronal …

Although substantial advances have been made in behavioral and pharmacological
treatments for addictions, moving treatment development to the next stage may require novel …

Background Cocaine use contines to be a significant public health problem world‐wide.
However, despite substantial research efforts, no pharmacotherapies are approved for the …

Introduction The COVID-19 pandemic was preceded by an ongoing overdose crisis and
linked to escalating drug overdose deaths in British Columbia (BC). At the outset of these …

Context No approved pharmacologic treatments for methamphetamine dependence exist.
Methamphetamine use is associated with high morbidity and is a major cofactor in the …