Polysaccharide-based nanomedicines targeting lung cancer

AA Bhat, G Gupta, KS Alharbi, O Afzal, ASA Altamimi… - Pharmaceutics, 2022 - mdpi.com
A primary illness that accounts for a significant portion of fatalities worldwide is cancer.
Among the main malignancies, lung cancer is recognised as the most chronic kind of cancer …

Inhalation delivery of repurposed drugs for lung cancer: approaches, benefits and challenges

P Kumbhar, A Manjappa, R Shah, NK Jha… - Journal of Controlled …, 2022 - Elsevier
Lung cancer (LC) is one of the leading causes of mortality accounting for almost 25% of
cancer deaths throughout the world. The shortfall of affordable and effective first-line …

A nanoreactor boosts chemodynamic therapy and ferroptosis for synergistic cancer therapy using molecular amplifier dihydroartemisinin

XX Yang, X Xu, MF Wang, HZ Xu, XC Peng… - Journal of …, 2022 - Springer
Background Chemodynamic therapy (CDT) relying on intracellular iron ions and H2O2 is a
promising therapeutic strategy due to its tumor selectivity, which is limited by the not enough …

A dihydroartemisinin‐loaded nanoreactor motivates anti‐cancer immunotherapy by synergy‐induced ferroptosis to activate Cgas/STING for reprogramming of …

LG Li, XX Yang, HZ Xu, TT Yu, QR Li… - Advanced …, 2023 - Wiley Online Library
Infiltration of tumor‐associated macrophages (TAM) characterized by an M2 phenotype is an
overriding feature in malignant tumors. Reprogramming TAM is the most cutting‐edge …

A hyaluronic acid functionalized self-nano-emulsifying drug delivery system (SNEDDS) for enhancement in ciprofloxacin targeted delivery against intracellular …

R Arshad, TA Tabish, MH Kiani, IM Ibrahim, G Shahnaz… - Nanomaterials, 2021 - mdpi.com
Ciprofloxacin (CIP), a potent anti-bacterial agent of the fluroquinolone family, shows poor
solubility and permeability, thus leading to the development of intracellular pathogens …

Dihydroartemisinin remodels macrophage into an M1 phenotype via ferroptosis-mediated DNA damage

LG Li, XC Peng, TT Yu, HZ Xu, N Han… - Frontiers in …, 2022 - frontiersin.org
Lung cancer recruits tumor-associated macrophages (TAMs) massively, whose
predominantly pro-tumor M2 phenotype leads to immunosuppression. Dihydroartemisinin …

An annexin V-FITC—propidium iodide-based method for detecting apoptosis in a non-small cell lung cancer cell line

R Kumar, A Saneja, AK Panda - Lung Cancer: Methods and Protocols, 2021 - Springer
Annexin V and propidium iodide staining is widely used for determining the cellular death
through apoptosis. In the presence of Ca 2+ ions, annexin V has a strong binding affinity for …

Perspectives and controversies regarding the use of natural products for the treatment of lung cancer

T Wen, L Song, S Hua - Cancer Medicine, 2021 - Wiley Online Library
Lung cancer is the leading cause of cancer‐related mortality both in men and women and
accounts for 18.4% of all cancer‐related deaths. Although advanced therapy methods have …

Polymer-drug conjugate, a potential therapeutic to combat breast and lung cancer

S Alven, X Nqoro, B Buyana, BA Aderibigbe - Pharmaceutics, 2020 - mdpi.com
Cancer is a chronic disease that is responsible for the high death rate, globally. The
administration of anticancer drugs is one crucial approach that is employed for the treatment …

[HTML][HTML] Development of nanoscale drug delivery systems of dihydroartemisinin for cancer therapy: A review

KH Wong, D Yang, S Chen, C He, M Chen - Asian Journal of …, 2022 - Elsevier
Abstract Dihydroartemisinin (DHA), a first-line antimalarial drug, has demonstrated great
anticancer effects in many types of tumors, including liver cancer, glioblastoma, and …