Increased glycolysis is the main source of energy supply in cancer cells that use this
metabolic pathway for ATP generation. Altered energy metabolism is a biochemical …

The prognosis in patients with pancreatic cancer is poor and this cancer is the fourth leading
cause of cancer-related death worldwide. Although surgical resection is the only curative …

Abstract Purpose: The transcription factor Forkhead box protein M1 (FOXM1) plays critical
roles in cancer development and progression. However, the regulatory role and underlying …

Abstract Lactate dehydrogenase-5 (LDH-5) catalyses the reversible transformation of
pyruvate to lactate, having a principal position in the anaerobic cellular metabolism …

Abstract Lactate dehydrogenase 5 (LDH5) is one of the five LDH isoenzymes and,
apparently, the most important for promoting anaerobic glycolysis. LDH5 is transcriptionally …

Abstract Background Lactate-dehydrogenase-5 (LDH-5) is an important isoenzyme
converting pyruvate to lactate under hypoxic conditions and might play an important role in …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of tumors, and its
incidence is rising worldwide. Survival can be improved when tumors are detected at an …

Purpose Lactate dehydrogenase 5 (LDH-5) regulates, under hypoxic conditions, the
anaerobic transformation of pyruvate to lactate for energy acquisition. Several studies have …

Pancreatic cancer is one of the leading causes of cancer death worldwide. Its high mortality
rate has remained unchanged for years. Radiotherapy and surgery are considered standard …

Background Pancreatic adenocarcinoma (PAAD) a highly lethal malignancy. The current
use of clinical parameters may not accurately predict the clinical outcome, which further …