Acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by the
malignant clonal expansion of lymphoid hematopoietic precursors. It is regulated by various …

Bone marrow is the primary site of blood cell production in adults and serves as the source
of osteoblasts and osteoclasts that maintain bone homeostasis. The medullary …

Natural killer (NK) cells are innate lymphocytes that eliminate virus-infected and cancer cells
by cytotoxicity and cytokine secretion. In addition to circulating NK cells, distinct tissue …

MicroRNAs (miRNAs) are emerging as a significant modulator of immunity, and their
abnormal expression/activity has been linked to numerous human disorders, such as …

Simple Summary The transcription factor RUNX family plays a crucial role in the formation of
osteoblasts from bone marrow mesenchymal stem cells, contributing to bone development …

Redox metabolism plays a central role in the cellular metabolism network, involves catabolic
and anabolic reactions of diverse biomass, and determines the redox state of cells. It can be …

The effect of glycolysis remains largely elusive in acute T lymphoblastic leukemia (T-ALL).
Increasing evidence has indicated that the dysregulation of miRNAs is involved in glycolysis …

Malignant transformation of T-cell progenitors causes T-cell acute lymphoblastic leukemia (T-
ALL), an aggressive childhood lymphoproliferative disorder. Activating mutations of Notch …

Abstract p53 deficiency and Myc dysregulation are frequently associated with cancer.
However, the molecular mechanisms linking these two major oncogenic events are poorly …

Background Enhancer reprogramming plays a significant role in the heterogeneity of cancer.
However, we have limited knowledge about the impact of chromatin remodeling in B-Cell …