Despite clinical and scientific advancements, heart failure is the major cause of morbidity
and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the …

Diabetes mellitus (DM) and cardiovascular complications are two unmet medical
emergencies that can occur together. The rising incidence of heart failure in diabetic …

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere
protein-encoding genes (ie genotype-positive HCM). In an increasing number of patients …

This study aimed at investigating the SGLT2 expression in human cardiomyocytes. Human
studies evaluating cardiomyocyte SGLT2s expression are limited. To better clarify this issue …

The pivotal role of inflammation in the pathophysiology of heart-failure (HF) development
and progression has long been recognized. High blood levels of pro-inflammatory and …

Diabetic Mellitus has been characterized as the most prevalent disease throughout the
globe associated with the serious morbidity and mortality of vital organs. Cardiomyopathy is …

Fabry disease (FD) is a lysosomal storage disorder caused by mutations in the gene for α-
galactosidase A, inducing a progressive accumulation of globotriaosylceramide (GB3) and …

As the global demographic landscape continues to shift towards an aged population, so
does the medical and socioeconomic burden of cardiovascular diseases. Indeed, ageing is …

Sepsis is a systemic inflammatory response syndrome caused by a variety of dysregulated
responses to host infection with life-threatening multi-organ dysfunction. Among the injuries …

Giant mitochondria are frequently observed in different disease models within the brain,
kidney, and liver. In cardiac muscle, these enlarged organelles are present across diverse …