Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular
matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic …

Bile acids (BAs) are produced from cholesterol in the liver and are termed primary BAs.
Primary BAs are conjugated with glycine and taurine in the liver and then released into the …

Fibrosis, a process caused by excessive deposition of extracellular matrix (ECM), is a
common cause and outcome of organ failure and even death. Researchers have made …

Cirrhosis is a severe form of liver fibrosis that results in the irreversible replacement of liver
tissue with scar tissue in the liver. Environmental toxicity, infections, metabolic causes, or …

microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either
blocking translation or inducing degradation of target mRNA. miRNAs play essential roles in …

Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease and
ranges from steatosis to steatohepatitis and to liver fibrosis. Lipotoxicity in hepatocytes …

When hepatocytes are damaged severely, a variety of signaling pathways will be triggered
by inflammatory factors and cytokines involving in the process of hepatic fibrosis. The …

Novel insights into the epigenetic control of chronic liver diseases are now emerging.
Recent advances in our understanding of the critical roles of DNA methylation, histone …

Fibrosis is a common pathological state characterized by the excessive accumulation of
extracellular matrix components, but the pathogenesis of the disease is still not clear …

Liver fibrosis, characterized by scar tissue formation, can ultimately result in liver failure. It's a
major cause of morbidity and mortality globally, often associated with chronic liver diseases …