Loss of muscle proteins is a deleterious consequence of chronic kidney disease (CKD) that
causes a decrease in muscle strength and function, and can lead to a reduction in quality of …

Muscle RING finger 1 (MuRF1) and muscle atrophy F-box (MAFbx)/atrogin-1 were identified
more than 10 years ago as two muscle-specific E3 ubiquitin ligases that are increased …

In patients with chronic kidney disease (CKD), loss of cellular proteins increases the risks of
morbidity and mortality. Persistence of muscle protein catabolism in CKD results in striking …

Metabolic dysfunction contributes to the clinical deterioration observed in advanced cancer
patients and is characterized by weight loss, skeletal muscle wasting, and atrophy of the …

Skeletal muscle atrophy is a debilitating response to starvation and many systemic diseases
including diabetes, cancer, and renal failure. We had proposed that a common set of …

All proteins in mammalian cells are continually being degraded and replaced. In the cytosol,
nucleus, and organelles, individual proteins are degraded at widely differing rates; some …

All intracellular proteins and many extracellular proteins are continually “turning over”; ie,
they are being hydrolyzed to their constituent amino acids and replaced by new synthesis …

Nonvolatile acid is produced from the metabolism of organic sulfur in dietary protein and the
production of organic anions during the combustion of neutral foods. Organic anion salts that …

About half of all cancer patients show a syndrome of cachexia, characterized by loss of
adipose tissue and skeletal muscle mass. Such patients have a decreased survival time …

Acid–base homeostasis exerts a major influence on protein function, thereby critically
affecting tissue and organ performance. Deviations of systemic acidity in either direction can …