The hypocretins (H crts), also known as orexins, are two peptides derived from a single
precursor produced in the posterior lateral hypothalamus. Over the past decade, the orexin …

Pituitary adenylate cyclase activating polypeptide (PACAP) is a pleiotropic and
multifunctional peptide exerting its effects via 3 main receptors (PAC1, VPAC1 and VPAC2) …

Orexins are produced specifically by neurons located in the lateral hypothalamus. Recent
results suggested peripheral actions of orexins. Therefore, we analyzed the mRNA …

The pharmacology of various peptide and non‐peptide ligands was studied in Chinese
hamster ovary (CHO) cells stably expressing human orexin‐1 (OX1) or orexin‐2 (OX2) …

Orexin A (OXA) and orexin B were originally isolated as hypothalamic peptides regulating
sleep, wakefulness and feeding. However, growing evidence suggests that orexins have …

Orexins (hypocretins) are critically involved in coordinating appropriate physiological and
behavioral responses to aversive and threatening stimuli. Acute stressors engage orexin …

Pituitary adenylate cyclase activating polypeptide (PACAP) was first isolated from
hypothalamic extracts on the basis of its ability to stimulate cAMP formation in pituitary cells …

Although starvation-induced biochemical and metabolic changes are perceived by the
hypothalamus, the adrenal gland plays a key role in the integration of metabolic activity and …

Orexins, also named hypocretins, were discovered in 1998 by subtractive cDNA cloning or
orphan receptor technologies. Prepro-orexin is enzymatically matured into two peptides …

Hypocretins, also named as orexins, are excitatory neuropeptides secreted by neurons
specifically located in lateral hypothalamus and perifornical areas. Orexinergic fibers are …