In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance …

Zebrafish (Danio rerio) is a valuable non-mammalian vertebrate model widely used to study
development and disease, including more recently cancer. The evolutionary conservation of …

Zebrafish are teleosts (bony fish) that share with mammals a common ancestor belonging to
the phylum Osteichthyes, from which their endoskeletal systems have been inherited …

Pancreatic ductal adenocarcinoma (PDAC) tumors are characterized by a desmoplastic
reaction resulting in dense deposition of collagen that is known to promote cancer …

Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase. The dysregulation of SYK is
closely related to the occurrence and development of allergic diseases, autoimmune …

Triple-negative breast cancer (TNBC) is a highly aggressive and recurrent type of breast
carcinoma that is associated with poor patient prognosis. Because of the limited efficacy of …

Zebrafish have proven to be a valuable model to study human cancer biology with the
ultimate aim of developing new therapies. Danio rerio are amenable to in vivo imaging, high …

Cancer is becoming more common worldwide, impacting the vast majority of people. As a
result, new anticancer drugs are currently being created, and their safety is still being …

Macrophages (MΦ) play a critical role in tumor growth, immunosuppression, and inhibition
of adaptive immune responses in cancer. Hence, targeting signaling pathways in MΦs that …

Lethal and incurable bone metastasis is one of the main causes of death in multiple types of
cancer. A small subpopulation of cancer stem/progenitor-like cells (CSCs), also known as …