The enlargement and species-specific elaboration of the cerebral neocortex during
evolution holds the secret to the mental abilities of humans; however, the genetic origin and …

Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the
foundation of nervous system function. This inhibition is largely mediated by the …

The development of the nervous system involves a coordinated succession of events
including the migration of GABAergic (γ-aminobutyric-acid-releasing) neurons from ventral …

Understanding the organizational logic of neural circuits requires deciphering the biological
basis of neuronal diversity and identity, but there is no consensus on how neuron types …

Diverse subsets of cortical interneurons have vital roles in higher-order brain functions. To
investigate how this diversity is generated, here we used single-cell RNA sequencing to …

The ventricular-subventricular zone (V-SVZ), on the walls of the lateral ventricles, harbors
the largest neurogenic niche in the adult mouse brain. Previous work has shown that neural …

A key obstacle to understanding neural circuits in the cerebral cortex is that of unraveling the
diversity of GABAergic interneurons. This diversity poses general questions for neural circuit …

Human induced pluripotent stem cells (hiPSCs) are emerging as a tool for understanding
human brain development at cellular, molecular, and genomic levels. Here we show that …

The nervous system adapts to experience by inducing a transcriptional program that controls
important aspects of synaptic plasticity. Although the molecular mechanisms of experience …

Potassium channels are responsible for the selective permeation of K+ ions across cell
membranes. K+ ions permeate in single file through the selectivity filter, a narrow pore lined …