Targeting the blood-brain barrier for the delivery of stroke therapies

A D'Souza, KM Dave, RA Stetler… - Advanced drug delivery …, 2021 - Elsevier
A variety of neuroprotectants have shown promise in treating ischemic stroke, yet their
delivery to the brain remains a challenge. The endothelial cells lining the blood-brain barrier …

Brain‐derived neurotrophic factor and its potential therapeutic role in stroke comorbidities

W Liu, X Wang, M O'Connor, G Wang, F Han - Neural plasticity, 2020 - Wiley Online Library
With the rise in the aging global population, stroke comorbidities have become a serious
health threat and a tremendous economic burden on human society. Current therapeutic …

The role of BDNF in multiple sclerosis neuroinflammation

V Nociti, M Romozzi - International Journal of Molecular Sciences, 2023 - mdpi.com
Multiple sclerosis (MS) is a chronic, inflammatory, and degenerative disease of the central
nervous system (CNS). Inflammation is observed in all stages of MS, both within and around …

Circulating brain-derived neurotrophic factor as a potential biomarker in stroke: a systematic review and meta-analysis

H Mojtabavi, Z Shaka, S Momtazmanesh… - Journal of Translational …, 2022 - Springer
Background Stroke, an acute cerebrovascular event, is a leading cause of disability, placing
a significant psycho-socioeconomic burden worldwide. The adaptation and reorganization …

Serum BDNF levels in acute stroke: a systematic review and meta-analysis

E Karantali, D Kazis, V Papavasileiou, A Prevezianou… - Medicina, 2021 - mdpi.com
Background and objectives: Brain-derived neurotrophic factor (BDNF) is one of the most
studied neurotrophins. Low BDNF concentrations have been noted in patients with …

Effects of virtual reality-based motor control training on inflammation, oxidative stress, neuroplasticity and upper limb motor function in patients with chronic stroke: a …

CY Huang, WC Chiang, YC Yeh, SC Fan, WH Yang… - BMC neurology, 2022 - Springer
Background Immersive virtual reality (VR)-based motor control training (VRT) is an
innovative approach to improve motor function in patients with stroke. Currently, outcome …

Neurovascular unit as a source of ischemic stroke biomarkers—limitations of experimental studies and perspectives for clinical application

A Steliga, P Kowiański, E Czuba, M Waśkow… - Translational stroke …, 2020 - Springer
Cerebral stroke, which is one of the most frequent causes of mortality and leading cause of
disability in developed countries, often leads to devastating and irreversible brain damage …

Cognitive rehabilitation improves ischemic stroke-induced cognitive impairment: role of growth factors

F Farokhi-Sisakht, M Farhoudi… - Journal of Stroke and …, 2019 - Elsevier
Cognitive dysfunction is the most common nonphysical impairment in the stroke survivors.
This impairment has a negative impact on patients' quality of life affects their daily living …

Promoting neuroregeneration after perinatal arterial ischemic stroke: neurotrophic factors and mesenchymal stem cells

N Wagenaar, CGM De Theije, LS De Vries… - Pediatric …, 2018 - nature.com
Newborns suffering from perinatal arterial ischemic stroke (PAIS) are at risk of
neurodevelopmental problems. Current treatment options for PAIS are limited and mainly …

[HTML][HTML] Increased serum brain-derived neurotrophic factor with high-intensity interval training in stroke patients: a randomized controlled trial

CC Hsu, TC Fu, SC Huang, CPC Chen… - Annals of physical and …, 2021 - Elsevier
Background Physiological adaptations of stroke patients after high-intensity interval training
(HIIT) and moderate-intensity continuous training (MICT) remain unclear. Objective This …