Biosynthesis, extraction, detection and pharmacological attributes of vinblastine and vincristine, two important chemotherapeutic alkaloids of Catharanthus roseus (L.) …

A Paul, K Acharya, N Chakraborty - South African Journal of Botany, 2023 - Elsevier
The demand for natural product is growing their interest in our daily life. It makes
Catharanthus roseus (L.) G. Don a crucial member of family Apocynaceae due to having its …

Proactive therapeutic drug monitoring of vincristine in pediatric and adult cancer patients: current supporting evidence and future efforts

CY Wu, GT Li, CC Chu, HL Guo, WR Fang, T Li… - Archives of …, 2023 - Springer
Vincristine (VCR), an effective antitumor drug, has been utilized in several polytherapy
regimens for acute lymphoblastic leukemia, neuroblastoma and rhabdomyosarcoma …

[HTML][HTML] Development of the DNA-based voltammetric biosensor for detection of vincristine as anticancer drug

M Abbasi, F Alsaikhan, RF Obaid, S Jahani… - Frontiers in …, 2023 - frontiersin.org
In the article presented herein, a deoxyribonucleic acid (DNA) biosensor is introduced for
Vincristine determination in pharmaceutical preparations based on the modification of …

[HTML][HTML] Targeting a xenobiotic transporter to ameliorate vincristine-induced sensory neuropathy

Y Li, T Drabison, M Nepal, RH Ho, AF Leblanc… - JCI insight, 2023 - ncbi.nlm.nih.gov
Vincristine is a widely used chemotherapeutic drug for the treatment of multiple malignant
diseases that causes a dose-limiting peripheral neurotoxicity. There is no clinically effective …

Vincristine Disposition and Neurotoxicity Are Unchanged in Humanized CYP3A5 Mice

Y Li, Y Kazuki, T Drabison, K Kobayashi, K Fujita… - Drug Metabolism and …, 2024 - ASPET
Previous studies have suggested that the incidence of vincristine-induced peripheral
neuropathy (VIPN) is potentially linked with cytochrome P450 (CYP) 3A5, a polymorphic …

Targeting OCT2 with duloxetine to prevent oxaliplatin-induced peripheral neurotoxicity

MR Nepal, H Taheri, Y Li, Z Talebi, ME Uddin… - Cancer research …, 2022 - AACR
Oxaliplatin-induced peripheral neurotoxicity (OIPN) is a debilitating side effect that afflicts
approximately 90% of patients that is initiated by OCT2-dependent uptake of oxaliplatin in …

Quantification of vincristine and tariquidar by liquid chromatography‐tandem mass spectrometry in mouse whole blood using volumetric absorptive microsampling for …

SPA Rosser, C Atkinson, CE Nath… - Journal of Separation …, 2022 - Wiley Online Library
A liquid chromatography‐tandem mass spectrometry method was developed and validated
for the simultaneous quantification of vincristine and tariquidar in 10 μL of mouse whole …

[HTML][HTML] A novel highly sensitive UHPLC-MS/MS method for monitoring vincristine in plasma and vitreous humor samples with potential application in retinoblastoma …

P Kozlik, J Sirc, AI Cocarta, Z Bosakova - Microchemical Journal, 2022 - Elsevier
Vincristine is a chemotherapeutic agent which is effective in treating various types of cancer,
including retinoblastoma, the most common malignant intraocular tumor in children. There is …

[HTML][HTML] Pharmacokinetics, bioavailability and tissue distribution of chitobiose and chitotriose in rats

M Chen, J Jin, X Ji, K Chang, J Li, L Zhao - Bioresources and …, 2022 - Springer
Chitooligosaccharides (COSs) have various physiological activities and broad application
prospects; however, their pharmacokinetics and tissue distribution remain unclear. In this …

[HTML][HTML] An Efficient UPLC-MS/MS Method for the Determination of Pyrroloquinoline Quinone in Rat Plasma and Its Application to a Toxicokinetic Study

Q Sun, Y Hong, Z Yang, P He, C Chen, J Wang… - Molecules, 2022 - mdpi.com
Pyrroloquinoline quinone (PQQ) is a powerful antioxidant coenzyme existing in diet,
benefiting growth, development, cognition function, and the repair of damaged organs …