Chromatin provides both a means to accommodate a large amount of genetic material in a
small space and a means to package the same genetic material in different chromatin states …

Cellular DNA is constantly being damaged by numerous internal and external mutagenic
factors. Probably the most severe type of insults DNA could suffer are the double-strand …

Abstract Fun30 is a Swi2/Snf2 homolog in budding yeast that has been shown to remodel
chromatin both in vitro and in vivo. We report that Fun30 plays a key role in homologous …

DNA double-strand breaks (DSBs), which arise following exposure to a number of
endogenous and exogenous agents, can be repaired by either the homologous …

Endogenous retroviruses (ERVs) can confer benefits to their host but present a threat to
genome integrity if not regulated correctly. Here we identify the SWI/SNF-like remodeler …

ATP-dependent nucleosome remodelers use ATP hydrolysis to shift, evict and exchange
histone dimers or octamers and have well-established roles in transcription. Earlier work has …

Centromeres are the chromosomal loci essential for faithful chromosome segregation during
cell division. Although centromeres are transcribed and produce non-coding RNAs …

Centromeres are specialized domains of heterochromatin that provide the foundation for the
kinetochore. Centromeric heterochromatin is characterized by specific histone modifications …

The centromere is the genetic locus that specifies the site of kinetochore assembly, where
the chromosome will attach to the kinetochore microtubule. The pericentromere is the …

In eukaryotic cells, local chromatin structure and chromatin organization in the nucleus both
influence transcriptional regulation. At the local level, the Fun30 chromatin remodeler Fft3 is …