Hypertension is a major risk factor for heart attack, produce atherosclerosis (hardening of the
arteries), congestive heart failure, stroke, kidney infection, blindness, end-stage renal …

The clinical variability seen in BAV aortopathy, in terms of phenotype and natural/clinical
history, suggests complex interactions between primary genetic defects, other modifier …

Recently pseudorabies outbreaks have occurred in many vaccinated farms in China. To
identify genetic characteristics of pseudorabies virus (PRV) strains, we obtained the …

Aortic aneurysms are relatively common maladies that may lead to the devastating
consequence of aortic rupture. AAAs (abdominal aortic aneurysms) and TAAs (thoracic …

© AME Publishing Company. All rights reserved. Ann Cardiothorac Surg 2013; 2 (1): 83-91
www. annalscts. com an intrinsically 'weaker'aorta. In addition, the presence of valve …

Bicuspid aortic valve (BAV) is the most common type of congenital cardiac malformation.
Patients with a BAV have a predisposition for the development of thoracic aortic aneurysm …

Background Recently, we demonstrated that losartan reduced the aortic root dilatation rate
(AoDR) in adults with Marfan syndrome (MFS); however, responsiveness was diverse. The …

570 Circ Cardiovasc Genet October 2012 semilunar (aortic and pulmonary) valve leaflets. 3,
8 The development of the outflow tract and semilunar valve is complex and involves …

Herein we summarize the current knowledge on the bicuspid aortic valve (BAV)-associated
aortopathy regarding clinical presentation and disease sub-classification, genetic …

Marfan syndrome is consequent upon mutations in FBN1, which encodes the extracellular
matrix microfibrillar protein fibrillin-1. The phenotype is characterised by development of …