Extracellular vesicles (EVs) are small lipid membrane vesicles that are secreted from almost
all kinds of cells into the extracellular space. EVs are widely accepted to be involved in …

Histones are intra-nuclear cationic proteins that are present in all eukaryotic cells and are
highly conserved across species. Within the nucleus, they provide structural stability to …

Histones and their post-translational modifications have key roles in chromatin remodeling
and gene transcription. Besides intranuclear functions, histones act as damage-associated …

The YAP and TAZ paralogs are transcriptional co-activators recruited to target sites by TEAD
proteins. Here, we show that YAP and TAZ are also recruited by JUNB (a member of the AP …

Cell death and inflammation are key pathologic responses of acute pancreatitis (AP), the
leading cause of hospital admissions for gastrointestinal disorders. It is becoming …

Systemic lupus erythematosus (SLE) is an archetypical systemic, autoimmune inflammatory
disease characterized by the production of autoantibodies to multiple nuclear Ags. Apoptotic …

Recognition and removal of apoptotic and necrotic cells must be efficient and highly
controlled to avoid excessive inflammation and autoimmune responses to self. The …

Ageing is a complex and multifactorial process characterized by the accumulation of many
forms of damage at the molecular, cellular, and tissue level with advancing age. Ageing …

Apoptotic cells are considered the source of DNA, histones, and nucleoprotein complexes
that drive the production of autoantibodies in systemic lupus erythematosus. However, the …

Objectives: Multiple organ dysfunction syndrome is characterized by simultaneous multiple
organ failure, which is the leading cause of death in acute critically ill patients. However …