Progress towards biocompatible intracortical microelectrodes for neural interfacing applications

M Jorfi, JL Skousen, C Weder… - Journal of neural …, 2014 - iopscience.iop.org
To ensure long-term consistent neural recordings, next-generation intracortical
microelectrodes are being developed with an increased emphasis on reducing the neuro …

Implanted neural interfaces: biochallenges and engineered solutions

WM Grill, SE Norman… - Annual review of …, 2009 - annualreviews.org
Neural interfaces are connections that enable two-way exchange of information with the
nervous system. These connections can occur at multiple levels, including with peripheral …

Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration

GC McConnell, HD Rees, AI Levey… - Journal of neural …, 2009 - iopscience.iop.org
Prosthetic devices that are controlled by intracortical electrodes recording one's' thoughts'
are a reality today, and no longer merely in the realm of science fiction. However …

Stab injury and device implantation within the brain results in inversely multiphasic neuroinflammatory and neurodegenerative responses

KA Potter, AC Buck, WK Self… - Journal of neural …, 2012 - iopscience.iop.org
An estimated 25 million people in the US alone rely on implanted medical devices,∼ 2.5
million implanted within the nervous system. Even though many devices perform adequately …

Dexamethasone-coated neural probes elicit attenuated inflammatory response and neuronal loss compared to uncoated neural probes

Y Zhong, RV Bellamkonda - Brain research, 2007 - Elsevier
Glial scar formation around implanted silicon neural probes compromises their ability to
facilitate long-term recordings. One approach to modulate the tissue reaction around …

BBB leakage, astrogliosis, and tissue loss correlate with silicon microelectrode array recording performance

NF Nolta, MB Christensen, PD Crane, JL Skousen… - Biomaterials, 2015 - Elsevier
The clinical usefulness of brain machine interfaces that employ penetrating silicon
microelectrode arrays is limited by inconsistent performance at chronic time points. While it …

Mechanically adaptive intracortical implants improve the proximity of neuronal cell bodies

JP Harris, JR Capadona, RH Miller… - Journal of neural …, 2011 - iopscience.iop.org
The hypothesis is that the mechanical mismatch between brain tissue and microelectrodes
influences the inflammatory response. Our unique, mechanically adaptive polymer …

[图书][B] Indwelling neural implants: strategies for contending with the in vivo environment

WM Reichert - 2007 - taylorfrancis.com
Despite enormous advances made in the development of external effector prosthetics over
the last quarter century, significant questions remain, especially those concerning signal …

A comparison of the tissue response to chronically implanted Parylene-C-coated and uncoated planar silicon microelectrode arrays in rat cortex

BD Winslow, MB Christensen, WK Yang, F Solzbacher… - Biomaterials, 2010 - Elsevier
In this study we employed a quantitative immunohistochemical approach to compare the
brain tissue response to planar silicon microelectrode arrays that were conformally coated …

In vivo deployment of mechanically adaptive nanocomposites for intracortical microelectrodes

JP Harris, AE Hess, SJ Rowan, C Weder… - Journal of neural …, 2011 - iopscience.iop.org
We recently introduced a series of stimuli-responsive, mechanically adaptive polymer
nanocomposites. Here, we report the first application of these bio-inspired materials as …