Progress towards biocompatible intracortical microelectrodes for neural interfacing applications
To ensure long-term consistent neural recordings, next-generation intracortical
microelectrodes are being developed with an increased emphasis on reducing the neuro …
microelectrodes are being developed with an increased emphasis on reducing the neuro …
Implanted neural interfaces: biochallenges and engineered solutions
WM Grill, SE Norman… - Annual review of …, 2009 - annualreviews.org
Neural interfaces are connections that enable two-way exchange of information with the
nervous system. These connections can occur at multiple levels, including with peripheral …
nervous system. These connections can occur at multiple levels, including with peripheral …
Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration
GC McConnell, HD Rees, AI Levey… - Journal of neural …, 2009 - iopscience.iop.org
Prosthetic devices that are controlled by intracortical electrodes recording one's' thoughts'
are a reality today, and no longer merely in the realm of science fiction. However …
are a reality today, and no longer merely in the realm of science fiction. However …
Stab injury and device implantation within the brain results in inversely multiphasic neuroinflammatory and neurodegenerative responses
An estimated 25 million people in the US alone rely on implanted medical devices,∼ 2.5
million implanted within the nervous system. Even though many devices perform adequately …
million implanted within the nervous system. Even though many devices perform adequately …
Dexamethasone-coated neural probes elicit attenuated inflammatory response and neuronal loss compared to uncoated neural probes
Y Zhong, RV Bellamkonda - Brain research, 2007 - Elsevier
Glial scar formation around implanted silicon neural probes compromises their ability to
facilitate long-term recordings. One approach to modulate the tissue reaction around …
facilitate long-term recordings. One approach to modulate the tissue reaction around …
BBB leakage, astrogliosis, and tissue loss correlate with silicon microelectrode array recording performance
NF Nolta, MB Christensen, PD Crane, JL Skousen… - Biomaterials, 2015 - Elsevier
The clinical usefulness of brain machine interfaces that employ penetrating silicon
microelectrode arrays is limited by inconsistent performance at chronic time points. While it …
microelectrode arrays is limited by inconsistent performance at chronic time points. While it …
Mechanically adaptive intracortical implants improve the proximity of neuronal cell bodies
JP Harris, JR Capadona, RH Miller… - Journal of neural …, 2011 - iopscience.iop.org
The hypothesis is that the mechanical mismatch between brain tissue and microelectrodes
influences the inflammatory response. Our unique, mechanically adaptive polymer …
influences the inflammatory response. Our unique, mechanically adaptive polymer …
[图书][B] Indwelling neural implants: strategies for contending with the in vivo environment
WM Reichert - 2007 - taylorfrancis.com
Despite enormous advances made in the development of external effector prosthetics over
the last quarter century, significant questions remain, especially those concerning signal …
the last quarter century, significant questions remain, especially those concerning signal …
A comparison of the tissue response to chronically implanted Parylene-C-coated and uncoated planar silicon microelectrode arrays in rat cortex
In this study we employed a quantitative immunohistochemical approach to compare the
brain tissue response to planar silicon microelectrode arrays that were conformally coated …
brain tissue response to planar silicon microelectrode arrays that were conformally coated …
In vivo deployment of mechanically adaptive nanocomposites for intracortical microelectrodes
We recently introduced a series of stimuli-responsive, mechanically adaptive polymer
nanocomposites. Here, we report the first application of these bio-inspired materials as …
nanocomposites. Here, we report the first application of these bio-inspired materials as …