New technologies have enabled the investigation of biology and human health at an
unprecedented scale and in multiple dimensions. These dimensions include a myriad of …

Transcriptional activation throughout the eukaryotic lineage has been tightly linked with
disruption of nucleosome organization at promoters, enhancers, silencers, insulators and …

In animal embryos, transcription is mostly silent for several cell divisions, until the release of
the first major wave of embryonic transcripts through so-called zygotic genome activation …

Motivation: Advances in high-throughput sequencing have resulted in rapid growth in large,
high-quality datasets including those arising from transcription factor (TF) ChIP-seq …

In metazoans, lysosomes are the center for the degradation of macromolecules and play a
key role in a variety of cellular processes, such as autophagy, exocytosis and membrane …

The MEME Suite is a powerful, integrated set of web-based tools for studying sequence
motifs in proteins, DNA and RNA. Such motifs encode many biological functions, and their …

Abstract RSAT (Regulatory Sequence Analysis Tools) enables the detection and the
analysis of cis-regulatory elements in genomic sequences. This software suite performs (i) …

Genome-wide binding data from transcription factor ChIP-seq experiments is the best source
of information for inferring the relative DNA-binding affinity of these proteins in vivo …

Abstract RSAT (Regulatory Sequence Analysis Tools) is a suite of modular tools for the
detection and the analysis of cis-regulatory elements in genome sequences. Its main …

Interventions that delay ageing mobilize mechanisms that protect and repair cellular
components,,, but it is unknown how these interventions might slow the functional decline of …