Shear stress augments mitochondrial ATP generation that triggers ATP release and Ca2+ signaling in vascular endothelial cells

K Yamamoto, H Imamura… - American Journal of …, 2018 - journals.physiology.org
Vascular endothelial cells (ECs) sense and transduce hemodynamic shear stress into
intracellular biochemical signals, and Ca2+ signaling plays a critical role in this …

[HTML][HTML] Mitochondria-localized caveolin in adaptation to cellular stress and injury

HN Fridolfsson, Y Kawaraguchi, SS Ali… - The FASEB …, 2012 - ncbi.nlm.nih.gov
We show here that the apposition of plasma membrane caveolae and mitochondria (first
noted in electron micrographs> 50 yr ago) and caveolae-mitochondria interaction regulates …

[图书][B] The biology of subcellular nitric oxide

T Rőszer - 2012 - books.google.com
This book fills in a gap in the NO literature. Recent progress in the field of NO-biology shows
that NO is generated within distinct cell compartments, including specific plasma membrane …

24S-hydroxycholesterol suppresses neuromuscular transmission in SOD1 (G93A) mice: A possible role of NO and lipid rafts

KA Mukhutdinova, MR Kasimov, AR Giniatullin… - Molecular and Cellular …, 2018 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the
initial denervation of skeletal muscle and subsequent death of motor neurons. A dying-back …

Different contributions of clathrin-and caveolae-mediated endocytosis of vascular endothelial cadherin to lipopolysaccharide-induced vascular hyperpermeability

Y Zhang, L Zhang, Y Li, S Sun, H Tan - PLoS One, 2014 - journals.plos.org
Vascular hyperpermeability induced by lipopolysaccharide (LPS) is a common pathogenic
process in cases of severe trauma and sepsis. Vascular endothelial cadherin (VE-cad) is a …

Novel peptide for attenuation of hypoxia-induced pulmonary hypertension via modulation of nitric oxide release and phosphodiesterase-5 activity

H Hu, S Zharikov, JM Patel - Peptides, 2012 - Elsevier
Pulmonary vascular endothelial nitric oxide (NO) synthase (eNOS)-derived NO is the major
stimulant of cyclic guanosine 5′-monophosphate (cGMP) production and NO/cGMP …

[HTML][HTML] Extracellular alkalinization induces endothelium-derived nitric oxide dependent relaxation in rat thoracic aorta

AC Celotto, VK Capellini, CBA Restini, CF Baldo… - Nitric Oxide, 2010 - Elsevier
AIM: To investigate the mechanism through which the extracellular alkalinization promotes
relaxation in rat thoracic aorta. METHODS: The relaxation response to NaOH-induced …

Enhanced phosphorylation of caveolar PKC-α limits peptide internalization in lung endothelial cells

TE Hutchinson, J Zhang, SL Xia, S Kuchibhotla… - Molecular and cellular …, 2012 - Springer
We previously reported that the vasoactive peptide 1 (P1,“SSWRRKRKESS”) modulates the
tension of pulmonary artery vessels through caveolar endothelial nitric oxide synthase …

Cell penetrating peptide-mediated Caveolae-dependent activation of lung endothelial nitric oxide synthase

T E. Hutchinson, H Hu, J M. Patel - Protein and Peptide Letters, 2016 - benthamdirect.com
Cell penetrating peptides can be used as therapeutic agents via modulation of selective cell
functions. Nitric oxide (NO) generated by vascular endothelial NO synthase (eNOS) plays a …

Peptide-stimulated angiogenesis: Role of lung endothelial caveolar signaling and nitric oxide

TE Hutchinson, JM Patel - Nitric Oxide, 2015 - Elsevier
Endothelial nitric oxide (NO) synthase (eNOS)-derived NO plays a critical role in the
modulation of angiogenesis in the pulmonary vasculature. We recently reported that an …