Summary Sporadic Creutzfeldt-Jakob disease is a fatal neurodegenerative disease caused
by misfolded prion proteins (PrP Sc). Effective therapeutics are currently not available and …

Neuroaxonal damage is the pathological substrate of permanent disability in various
neurological disorders. Reliable quantification and longitudinal follow-up of such damage …

Neurofilament light chain (NfL) is a promising fluid biomarker of disease progression for
various cerebral proteopathies. Here we leverage the unique characteristics of the …

Spinal muscular atrophy (SMA) is a neurodegenerative disease associated with severe
muscle atrophy and weakness in the limbs and trunk. We report interim efficacy and safety …

Objective: To determine if blood neurofilament light chain (NfL) protein can discriminate
between Parkinson disease (PD) and atypical parkinsonian disorders (APD) with equally …

Background Spinal cord injury (SCI) is a catastrophic injury that can cause irreversible motor
dysfunction with high disability. Exosomes participate in the transport of miRNAs and play an …

A majority of current disease-modifying therapeutic approaches for age-related
neurodegenerative diseases target their characteristic proteopathic lesions (α-synuclein …

Introduction We investigated plasma proteomic markers of astrocytopathy, brain
degeneration, plasticity, and inflammation in sporadic early-onset versus late-onset …

Background Neurofilament light chain protein (NfL) is a promising biomarker of
neurodegeneration. Objectives To determine whether plasma and CSF NfL (1) associate …

Objective: To test blood and CSF neurofilament light chain (NfL) levels in relation to disease
progression and survival in amyotrophic lateral sclerosis (ALS). Methods: Using an …