Molecular mechanisms in intimal hyperplasia

AC Newby, AB Zaltsman - The Journal of pathology, 2000 - Wiley Online Library
Intimal hyperplasia is the process by which the cell population increases within the
innermost layer of the arterial wall, such as occurs physiologically during closure of the …

Nuclear factor κB signaling in atherogenesis

MPJ De Winther, E Kanters, G Kraal… - … , and vascular biology, 2005 - Am Heart Assoc
Atherosclerosis is an inflammatory disease, characterized by the accumulation of
macrophage-derived foam cells in the vessel wall and accompanied by the production of a …

Oxidative stress as a regulator of gene expression in the vasculature

C Kunsch, RM Medford - Circulation research, 1999 - Am Heart Assoc
Oxidative stress and the production of intracellular reactive oxygen species (ROS) have
been implicated in the pathogenesis of a variety of diseases. In excess, ROS and their …

Nonsteroidal anti‐inflammatory drugs prevent early diabetic retinopathy via TNF‐α suppression

A M. Joussen, V Poulaki, N Mitsiades… - The FASEB …, 2002 - Wiley Online Library
Leukocyte adhesion to the diabetic retinal vasculature results in blood‐retinal barrier
breakdown, capillary nonperfusion, and endothelial cell injury and death. Intercellular …

Identification and Expression of δ-Isoforms of the Multifunctional Ca2+/Calmodulin-Dependent Protein Kinase in Failing and Nonfailing Human Myocardium

B Hoch, R Meyer, R Hetzer, EG Krause… - Circulation …, 1999 - Am Heart Assoc
Despite its importance for the regulation of heart function, little is known about the isoform
expression of the multifunctional Ca2+/calmodulin-dependent protein kinase (CaMKII) in …

Expandable stent with sliding and locking radial elements

TA Steinke, DH Koenig, J Zeltinger - US Patent 6,623,521, 2003 - Google Patents
The present invention provides a lumen support stent With a clear through-lumen for use in
a body lumen. The stent is formed from at least one series of sliding and locking radial …

Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis

AW Orr, NE Hastings, BR Blackman… - Journal of vascular …, 2010 - karger.com
Vascular smooth muscle cell (SMC) phenotypic modulation plays a key role in
atherosclerosis and is classically defined as a switch from a 'contractile'phenotype to a …

Early growth response-1 in cardiovascular pathobiology

LM Khachigian - Circulation research, 2006 - Am Heart Assoc
The immediate-early gene product and zinc finger transcription factor early growth response
(Egr)-1 plays a key master regulatory role in multiple cardiovascular pathological processes …

Hyperglycemia-induced activation of nuclear transcription factor kappaB in vascular smooth muscle cells.

KK Yerneni, W Bai, BV Khan, RM Medford… - Diabetes, 1999 - Am Diabetes Assoc
The transcriptional nuclear factor (NF)-kappaB can be activated by diverse stimuli such as
cytokines, mitogens, oxidative stress, and lipids, leading to the transactivation of several …

Accommodation of vascularized xenografts: expression of “protective genes” by donor endothelial cells in a host Th2 cytokine environment

FH Bach, C Ferran, P Hechenleitner, W Mark… - Nature medicine, 1997 - nature.com
Organ xenografts under certain circumstances survive in the presence of anti-graft
antibodies and complement, a situation referred to as “accommodation.” We find that the …