Abstract Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis, a form of
programmed cell death discovered and investigated in recent years. There are already …

Over the past 15 years, elegant studies have demonstrated that in certain conditions,
programed cell death resembles necrosis and depends on a unique molecular pathway with …

Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …

Necroptosis, a distinctive type of programmed cell death different from apoptosis or necrosis,
triggered by a series of death receptors such as tumor necrosis factor receptor 1 (TNFR1) …

Programmed necrosis is a new modulated cell death mode with necrotizing morphological
characteristics. Receptor interacting protein 1 (RIPK 1) is a critical mediator of the …

Receptor interacting protein kinase-1 and-3 (RIP1 and RIP3) are essential mediators of cell
death processes and participate in inflammatory responses. Our group recently …

Macrophages have a key functional role in the pathogenesis of various cardiovascular
diseases, such as atherosclerosis and aortic aneurysms. Their accumulation within the …

Receptor-interacting serine threonine kinase 1 (RIPK1) is a widely expressed kinase that is
essential for limiting inflammation in both mice and humans. Mice lacking RIPK1 die at birth …

Rupture of aortic aneurysm and dissection (AAD) remains a leading cause of death.
Progressive smooth muscle cell (SMC) loss is a crucial feature of AAD that contributes to …

The scaffolding function of receptor-interacting protein kinase 1 (RIPK1) regulates
prosurvival signaling and inflammatory gene expression, while its kinase activity mediates …