Nicotinamide riboside—the current state of research and therapeutic uses

M Mehmel, N Jovanović, U Spitz - Nutrients, 2020 - mdpi.com
Nicotinamide riboside (NR) has recently become one of the most studied nicotinamide
adenine dinucleotide (NAD+) precursors, due to its numerous potential health benefits …

Balancing NAD+ deficits with nicotinamide riboside: therapeutic possibilities and limitations

A Cercillieux, E Ciarlo, C Canto - Cellular and Molecular Life Sciences, 2022 - Springer
Alterations in cellular nicotinamide adenine dinucleotide (NAD+) levels have been observed
in multiple lifestyle and age-related medical conditions. This has led to the hypothesis that …

[HTML][HTML] A reduced form of nicotinamide riboside defines a new path for NAD+ biosynthesis and acts as an orally bioavailable NAD+ precursor

J Giroud-Gerbetant, M Joffraud, MP Giner… - Molecular …, 2019 - Elsevier
Objective A decay in intracellular NAD+ levels is one of the hallmarks of physiological
decline in normal tissue functions. Accordingly, dietary supplementation with NAD+ …

Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives

A Biţă, IR Scorei, MV Ciocîlteu, OE Nicolaescu… - Molecules, 2023 - mdpi.com
Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide
(NAD+) is involved in an extensive spectrum of human pathologies, including …

Emerging role of nicotinamide riboside in health and diseases

C Sharma, D Donu, Y Cen - Nutrients, 2022 - mdpi.com
Among all the NAD+ precursors, nicotinamide riboside (NR) has gained the most attention
as a potent NAD+-enhancement agent. This recently discovered vitamin, B3, has …

Yeast cell surface engineering of a nicotinamide riboside kinase for the production of β-nicotinamide mononucleotide via whole-cell catalysis

Z He, X Yang, X Tian, L Li, M Liu - ACS Synthetic Biology, 2022 - ACS Publications
β-Nicotinamide mononucleotide (NMN) has been widely used as a nutraceutical for self-
medication. The one-step conversion of nicotinamide riboside (NR) to β-NMN has been …

Enzymatic synthesis of high-titer nicotinamide mononucleotide with a new nicotinamide riboside kinase and an efficient ATP regeneration system

XL Qian, YS Dai, CX Li, J Pan, JH Xu, B Mu - Bioresources and …, 2022 - Springer
Background β-Nicotinamide mononucleotide (NMN) is the direct precursor of nicotinamide
coenzymes such as NAD+ and NADP+, which are widely applied in industrial biocatalysis …

Metabolic engineering of Escherichia coli for optimized biosynthesis of nicotinamide mononucleotide, a noncanonical redox cofactor

WB Black, D Aspacio, D Bever, E King, L Zhang… - Microbial cell …, 2020 - Springer
Background Noncanonical redox cofactors are emerging as important tools in cell-free
biosynthesis to increase the economic viability, to enable exquisite control, and to expand …

Synthesis of Nicotinamide Mononucleotide from Xylose via Coupling Engineered Escherichia coli and a Biocatalytic Cascade

U Ngivprom, P Lasin, P Khunnonkwao… - …, 2022 - Wiley Online Library
Abstract β‐Nicotinamide mononucleotide (NMN) has recently gained attention for a
nutritional supplement because it is an intermediate in the biosynthesis of nicotinamide …

Chemical and biochemical reactivity of the reduced forms of nicotinamide riboside

MV Makarov, F Hayat, B Graves, M Sonavane… - ACS chemical …, 2021 - ACS Publications
All life forms require nicotinamide adenine dinucleotide, NAD+, and its reduced form NADH.
They are redox partners in hundreds of cellular enzymatic reactions. Changes in the …