The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19
Q Hu, Y Xiong, GH Zhu, YN Zhang, YW Zhang… - MedComm, 2022 - Wiley Online Library
The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …
Potential resistance of SARS-CoV-2 main protease (Mpro) against protease inhibitors: lessons learned from HIV-1 protease
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome 2
(SARS-CoV-2), has been one of the most devastating pandemics of recent times. The lack of …
(SARS-CoV-2), has been one of the most devastating pandemics of recent times. The lack of …
X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the pathogen
that causes COVID-19, produces polyproteins 1a and 1ab that contain, respectively, 11 or …
that causes COVID-19, produces polyproteins 1a and 1ab that contain, respectively, 11 or …
SARS-CoV-2 Mpro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals
The main protease of SARS-CoV-2 (Mpro) is the most promising drug target against
coronaviruses due to its essential role in virus replication. With newly emerging variants …
coronaviruses due to its essential role in virus replication. With newly emerging variants …
NMR metabolomics methods for investigating disease
GA Nagana Gowda, D Raftery - Analytical chemistry, 2023 - ACS Publications
The field of metabolomics continues to grow exponentially as it contributes significantly to
numerous disciplines, including biomedicine, pharmacology, drug development, and …
numerous disciplines, including biomedicine, pharmacology, drug development, and …
[HTML][HTML] Viral proteases as therapeutic targets
T Majerová, J Konvalinka - Molecular aspects of medicine, 2022 - Elsevier
Some medically important viruses―including retroviruses, flaviviruses, coronaviruses, and
herpesviruses―code for a protease, which is indispensable for viral maturation and …
herpesviruses―code for a protease, which is indispensable for viral maturation and …
Progress on SARS-CoV-2 3CLpro inhibitors: inspiration from SARS-CoV 3CLpro peptidomimetics and small-molecule anti-inflammatory compounds
J Zhu, H Zhang, Q Lin, J Lyu, L Lu, H Chen… - Drug design …, 2023 - Taylor & Francis
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) currently poses a threat to human health. 3C-like …
syndrome coronavirus 2 (SARS-CoV-2) currently poses a threat to human health. 3C-like …
Analysis of SARS-CoV-2 isolates, namely the Wuhan strain, Delta variant, and Omicron variant, identifies differential immune profiles
There is an urgent need to better understand the impact of different severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants on immune response and disease …
syndrome coronavirus 2 (SARS-CoV-2) variants on immune response and disease …
SARS-CoV-2 nonstructural protein 6 triggers endoplasmic reticulum stress-induced autophagy to degrade STING1
P Jiao, W Fan, X Ma, R Lin, Y Zhao, Y Li, H Zhang… - Autophagy, 2023 - Taylor & Francis
ABSTRACT SARS-CoV-2 poses a substantial global threat owing to the emergence of
several highly transmissible variants. Autophagy is an intracellular degradation process that …
several highly transmissible variants. Autophagy is an intracellular degradation process that …
Predicted coronavirus Nsp5 protease cleavage sites in the human proteome
Background The coronavirus nonstructural protein 5 (Nsp5) is a cysteine protease required
for processing the viral polyprotein and is therefore crucial for viral replication. Nsp5 from …
for processing the viral polyprotein and is therefore crucial for viral replication. Nsp5 from …