The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

The role of fibronectin (FN) in tumorigenesis and malignant progression has been highly
controversial. Cancerous FN plays a tumor-suppressive role, whereas it is pro-metastatic …

Breast and prostate cancer research to date has largely been predicated on the use of cell
lines in vitro or in vivo. These limitations have led to the development of more clinically …

Dysregulated lipid metabolism is a prominent feature of prostate cancer that is driven by
androgen receptor (AR) signaling. Here we used quantitative mass spectrometry to define …

Background Resistance to androgen receptor signalling inhibitors (ARSIs) represents a
major clinical challenge in prostate cancer. We previously demonstrated that the ARSI …

Mass spectrometry offers the potential of acquiring high resolution data depicting the
functional status of a group of healthy or diseased individuals, according to different …

Background This study focuses on the role of lysosomal trafficking in prostate cancer, given
the essential role of lysosomes in cellular homoeostasis. Methods Lysosomal motility was …

The extracellular matrix (ECM) is a dynamic and organised extracellular network assembled
from proteins and carbohydrates exported from the cell. The ECM is critical for multicellular …

Hydrochloric acid (HCl) exposure causes asthma-like conditions, reactive airways
dysfunction syndrome, and pulmonary fibrosis. Heat Shock Protein 90 (HSP90) is a …

Alterations to the androgen receptor (AR) signalling axis and cellular metabolism are
hallmarks of prostate cancer. This study provides insight into both hallmarks by uncovering a …