Planar cell polarity (PCP) is an essential feature of animal tissues, whereby distinct polarity
is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by …

The establishment of planar cell polarity (PCP) in epithelial and mesenchymal cells is a
critical, evolutionarily conserved process during development and organogenesis. Analyses …

Growth factor signaling is required for cellular differentiation, tissue morphogenesis, and
tissue homeostasis. Misregulation of intracellular signal transduction can lead to …

Almost every vertebrate cell has a specialized cell surface projection called a primary cilium.
Although these structures were first described more than a century ago, the full scope of their …

Planar cell polarity (PCP) refers to the coordinated alignment of cell polarity across the
tissue plane. Key to the establishment of PCP is asymmetric partitioning of cortical PCP …

Cystic renal diseases are caused by mutations of proteins that share a unique subcellular
localization: the primary cilium of tubular epithelial cells. Mutations of the ciliary protein …

Most, if not all, cell types and tissues display several aspects of polarization. In addition to
the ubiquitous epithelial cell polarity along the apical-basolateral axis, many epithelial …

WNT/planar cell polarity (PCP) signaling pathway controls tissue polarity and cell movement
through the activation of RHOA, c-Jun N-terminal kinase (JNK), and nemo-like kinase (NLK) …

Abstract Signalling through Frizzled (Fz)/planar cell polarity (PCP) is a conserved
mechanism that polarizes cells along specific axes in a tissue. Genetic screens in …

Highlights•PCP complexes are robust to changes in protein levels.•Complexes may exist in
a signalosome-like assembly at cell junctions.•Wnt ligands play a conserved instructive …