The 26S proteasome is a large,∼ 2.5 MDa, multi-catalytic ATP-dependent protease complex
that serves as the degrading arm of the ubiquitin system, which is the major pathway for …

Skeletal muscle is one of the most abundant and highly plastic tissues. The ubiquitin–
proteasome system (UPS) is recognised as a major intracellular protein degradation system …

Engineered destruction of target proteins by recruitment to the cell's degradation machinery
has emerged as a promising strategy in drug discovery. The majority of molecules that …

Proteins are targeted to the proteasome by the attachment of ubiquitin chains, which are
markedly varied in structure. Three proteasome subunits–Rpn10, Rpn13, and Rpn1–can …

Protein modifications provide cells with exquisite temporal and spatial control of protein
function. Ubiquitin is among the most important modifiers, serving both to target hundreds of …

INTRODUCTION The ubiquitin-proteasome system comprises hundreds of distinct pathways
of degradation, which converge at the step of ubiquitin recognition by the proteasome. Five …

Protein secretion is an essential process for living organisms. In eukaryotes, this
encompasses numerous steps mediated by several hundred cellular proteins. The core …

The ubiquitin-proteasome system (UPS) is critical for protein quality control and regulating
protein lifespans. Following ubiquitination, UPS substrates bind multidomain receptors that …

The proteasome refers to a collection of complexes centered on the 20S proteasome core
particle (20S CP), a complex of 28 subunits that houses proteolytic sites in its hollow interior …

Ubiquitination is the major criteria for the recognition of a substrate-protein by the 26S
proteasome. Additionally, a disordered segment on the substrate—either intrinsic or induced …