Gastroenterologists frequently encounter pelvic floor disorders, which affect 10% to 15% of
the population. The anorectum is a complex organ that collaborates with the pelvic floor …

Rho GTPases are key molecular switches controlling the transduction of external signals to
cytoplasmic and nuclear effectors. In the last few years, the development of genetic and …

An increase in intracellular Ca 2+ is the primary trigger of contraction of gastrointestinal (GI)
smooth muscles. However, increasing the Ca 2+ sensitivity of the myofilaments by elevating …

The internal anal sphincter (IAS) plays an important role in the maintenance of fecal
continence since it generates tone and is responsible for> 70% of resting anal pressure …

The degree of phosphorylation of myosin light chain 20 (MLC20) is a major determinant of
force generation in smooth muscle. Myosin phosphatases (MPs) contain protein …

Smooth muscle sphincters exhibit basal tone and control passage of contents through
organs such as the gastrointestinal tract; loss of this tone leads to disorders such as faecal …

IT IS WELL KNOWN that smooth muscle contraction, whether spontaneous or following
pharmacological stimulation, occurs in two phases: the initial phasic followed by the tonic …

Objective To summarise current knowledge of Internal anal sphincter. Background The
internal anal sphincter (IAS) is the involuntary ring of smooth muscle in the anal canal and is …

A comprehensive genomic and proteomic, computational, and physiological approach was
employed to examine the (previously unexplored) role of microRNAs (miRNAs) as …

Background The efficacy of cell implantation via 3D-spheroids to treat basal tone in fecal
incontinence remains unclear. To address this, in this study, we aimed to identify cell …