Novel treatments for anorexia nervosa: insights from neuroplasticity research

JL Keeler, C Kan, J Treasure… - … Eating Disorders Review, 2023 - Wiley Online Library
Objective Treatment for anorexia nervosa (AN) remains challenging; there are no approved
psychopharmacological interventions and psychotherapeutic strategies have variable …

Triangulating brain alterations in anorexia nervosa: a multimodal investigation of magnetic resonance spectroscopy, morphometry and blood-based biomarkers

A Doose, FI Tam, I Hellerhoff, JA King, I Boehm… - Translational …, 2023 - nature.com
The acute state of anorexia nervosa (AN) is associated with widespread reductions in
cortical gray matter (GM) thickness and white matter (WM) volume, suspected changes in …

Predicting long-term outcome in anorexia nervosa: a machine learning analysis of brain structure at different stages of weight recovery

D Arold, F Bernardoni, D Geisler, A Doose… - Psychological …, 2023 - cambridge.org
BackgroundAnorexia nervosa (AN) is characterized by sizable, widespread gray matter
(GM) reductions in the acutely underweight state. However, evidence for persistent …

Differential alterations of amygdala nuclei volumes in acutely ill patients with anorexia nervosa and their associations with leptin levels

ML Wronski, D Geisler, F Bernardoni, M Seidel… - Psychological …, 2023 - cambridge.org
BackgroundThe amygdala is a subcortical limbic structure consisting of histologically and
functionally distinct subregions. New automated structural magnetic resonance imaging …

Lower region‐specific gray matter volume in females with atypical anorexia nervosa and anorexia nervosa

AE Lyall, L Breithaupt, C Ji, A Haidar… - … Journal of Eating …, 2024 - Wiley Online Library
Objective Few studies have focused on brain structure in atypical anorexia nervosa (atypical
AN). This study investigates differences in gray matter volume (GMV) between females with …

Dynamic functional connectivity in anorexia nervosa: alterations in states of low connectivity and state transitions

I Boehm, E Mennigen, D Geisler… - Journal of Child …, 2024 - Wiley Online Library
Background The onset of anorexia nervosa (AN) frequently occurs during adolescence and
is associated with preoccupation with body weight and shape and extreme underweight …

Effect of serum concentrations of IL-6 and TNF-α on brain structure in anorexia nervosa: a combined cross-sectional and longitudinal study

F Bernardoni, F Tam, DM Poitz, I Hellerhoff… - …, 2024 - nature.com
Previous studies of brain structure in anorexia nervosa (AN) have reported reduced gray
matter in underweight patients, which largely normalizes upon weight gain. One underlying …

Hypothalamic subregion alterations in anorexia nervosa and obesity: Association with appetite‐regulating hormone levels

H Alzaid, JJ Simon, G Brugnara… - … Journal of Eating …, 2024 - Wiley Online Library
Objective Anorexia nervosa (AN) and obesity are weight‐related disorders with imbalances
in energy homeostasis that may be due to hormonal dysregulation. Given the importance of …

Dynamic amygdala nuclei alterations in relation to weight status in anorexia nervosa are mediated by leptin

ML Wronski, F Bernardoni, K Bahnsen, M Seidel… - Journal of the American …, 2024 - Elsevier
Objective The amygdaloid complex is a subcortical limbic group of distinct nuclei. In a
previous patient-control study, differential amygdala nuclei alterations were found in acute …

Longitudinal changes in brain-derived neurotrophic factor (BDNF) but not cytokines contribute to hippocampal recovery in anorexia nervosa above increases in body …

JL Keeler, K Bahnsen, ML Wronski… - Psychological …, 2024 - cambridge.org
BackgroundPhysical sequelae of anorexia nervosa (AN) include a marked reduction in
whole brain volume and subcortical structures such as the hippocampus. Previous research …