Many extracellular signals elicit changes in the actin cytoskeleton, which are mediated
through an array of signaling proteins and pathways. One family of proteins that plays a role …

Dynamic reorganization of the actin cytoskeleton is fundamental to a number of cell
biological events. A variety of actin-regulatory proteins modulate polymerization and …

Human resistin is a cytokine that induces low-grade inflammation by stimulating monocytes.
Resistin-mediated chronic inflammation can lead to obesity, atherosclerosis, and other …

Cyclase-associated proteins (CAPs) are highly conserved actin monomer binding proteins
present in all eukaryotes. However, the mechanism by which CAPs contribute to actin …

Cofilin-ADF (actin-depolymerizing factor) is an essential driver of actin-based motility. We
discovered two proteins, p65 and p55, that are components of the actin-cofilin complex in a …

CAP (adenylyl cyclase-associated protein) was first identified in yeast as a protein that
regulates both the actin cytoskeleton and the Ras/cAMP pathway. Although the role in Ras …

Surface recognition and penetration are critical steps in the infection cycle of many plant
pathogenic fungi. In Magnaporthe oryzae, cAMP signaling is involved in surface recognition …

Cyclase-associated protein (CAP) is an evolutionarily conserved regulator of the G-actin/F-
actin ratio and, in yeast, is involved in regulating the adenylyl cyclase activity. We show that …

Regulation of actin cytoskeleton dynamics in dendritic spines is crucial for learning and
memory formation. Hence, defects in the actin cytoskeleton pathways are a biological trait of …

Actin-binding proteins are effectors of cell signalling and coordinators of cellular behaviour.
Research on the Dictyostelium actin cytoskeleton has focused both on the elucidation of the …