Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets

F Biasi, G Leonarduzzi, PI Oteiza… - Antioxidants & redox …, 2013 - liebertpub.com
Oxidative stress is thought to play a key role in the development of intestinal damage in
inflammatory bowel disease (IBD), because of its primary involvement in intestinal cells' …

HNE and cholesterol oxidation products in colorectal inflammation and carcinogenesis

D Rossin, S Calfapietra, B Sottero, G Poli… - Free Radical Biology and …, 2017 - Elsevier
Consistent experimental data suggest the importance of inflammation-associated oxidative
stress in colorectal cancer (CRC) pathogenesis. Inflammatory bowel disease with chronic …

[PDF][PDF] Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients

H Ansar, Z Mazloom, F Kazemi, N Hejazi - Saudi Med J, 2011 - emro.who.int
Objectives: To examine the effects of alpha-lipoic acid (ALA) treatment over a period of 2
months on fasting blood glucose (FBG), insulin resistance (IR), and glutathione peroxidase …

The effect of vitamin C and/or E supplementations on type 2 diabetic adult males under metformin treatment: A single-blinded randomized controlled clinical trial

A Abd El-Aal, EA Abd El-Ghffar, AA Ghali… - Diabetes & Metabolic …, 2018 - Elsevier
Background and aim Recently, there has been an increasing interest in the influence of
antioxidant vitamins on the efficacy of oral hypoglycemic therapy in type 2 diabetic patients …

[HTML][HTML] The Antidiabetic Effects and Modes of Action of the Balanites aegyptiaca Fruit and Seed Aqueous Extracts in NA/STZ-Induced Diabetic Rats

AS Zaky, M Kandeil, M Abdel-Gabbar, EM Fahmy… - Pharmaceutics, 2022 - mdpi.com
Diabetes mellitus (DM) is a chronic metabolic disorder that threatens human health.
Medicinal plants have been a source of wide varieties of pharmacologically active …

[HTML][HTML] Glycoxidative stress and cardiovascular complications in experimentally-induced diabetes: effects of antioxidant treatment

Ç Karasu - The open cardiovascular medicine journal, 2010 - ncbi.nlm.nih.gov
Diabetes mellitus (DM) is a common metabolic disease, representing a serious risk factor for
the development of cardiovascular complications, such as coronary heart disease …

Testicular oxidative damage and role of combined antioxidant supplementation in experimental diabetic rats

M Mohasseb, S Ebied, MAH Yehia… - Journal of physiology and …, 2011 - Springer
The present study was designated to assess oxidative damage and its effect on germ cell
apoptosis in testes of streptozotocin (STZ)-induced diabetic rats. The role of antioxidant …

[HTML][HTML] Alpha-lipoic acid regulates the autophagy of vascular smooth muscle cells in diabetes by elevating hydrogen sulfide level

X Qiu, K Liu, L Xiao, S Jin, J Dong, X Teng… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Dysfunctional vascular smooth muscle (VSM) plays a vital role in the process of
atherosclerosis in patients with type 2 diabetes mellitus (T2DM). Alpha-lipoic acid (ALA) can …

Histological changes in the heart and the proximal aorta in experimental diabetic rats fed with Piper sarmentsoum

H Soufy, TS Lin, S Das, Z Zakaria - African Journal of Traditional …, 2012 - ajol.info
Cardiovascular complications are one of the major causes of death in diabetes mellitus.
Piper sarmentosum (Ps) is an herb that possesses antihyperglycaemic effects. The main aim …

[HTML][HTML] The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT …

SY Lu, CY Wang, Y Jin, Q Meng, Q Liu, Z Liu, KX Liu… - Scientific reports, 2017 - nature.com
Recently, accumulating evidence has indicated that glucocorticoid-induced osteoporosis
(GIOP) is closely related to oxidative stress and apoptosis. Alpha-lipoic acid (LA), a naturally …