Age-related macular degeneration (AMD) is a complex eye disorder and is the leading
cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the …

Coronary artery disease is the leading global cause of mortality. Long recognized to be
heritable, recent advances have started to unravel the genetic architecture of the disease …

Background Visual impairment in elderly people is a considerable health problem that
significantly affects quality of life of millions worldwide. The magnitude of this issue is …

Distinct macrophage populations throughout the body display highly heterogeneous
transcriptional and epigenetic programs. Recent research has highlighted that these profiles …

Migraine is a debilitating neurological disorder affecting around one in seven people
worldwide, but its molecular mechanisms remain poorly understood. There is some debate …

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
adults over 50 years old. Genetic, epidemiological, and molecular studies are beginning to …

The human macula uniquely concentrates three carotenoids: lutein, zeaxanthin, and meso-
zeaxanthin. Lutein and zeaxanthin must be obtained from dietary sources such as green …

Background: Age-related macular degeneration is a leading cause of severe, irreversible
vision impairment in developed countries. The primary risk factors for the development of …

We screened variants on an exome-focused genotyping array in> 300,000 participants
(replication in> 280,000 participants) and identified 444 independent variants in 250 loci …

A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …