Interneuron types and their circuits in the basolateral amygdala

N Hájos - Frontiers in Neural Circuits, 2021 - frontiersin.org
The basolateral amygdala (BLA) is a cortical structure based on its cell types, connectivity
features, and developmental characteristics. This part of the amygdala is considered to be …

A cortico-amygdala neural substrate for endocannabinoid modulation of fear extinction

O Gunduz-Cinar, LI Castillo, M Xia, E Van Leer… - Neuron, 2023 - cell.com
Preclinical and clinical studies implicate endocannabinoids (eCBs) in fear extinction, but the
underlying neural circuit basis of these actions is unclear. Here, we employed in vivo …

Dynorphin/kappa opioid receptor system regulation on amygdaloid circuitry: Implications for neuropsychiatric disorders

A Limoges, HE Yarur, HA Tejeda - Frontiers in Systems Neuroscience, 2022 - frontiersin.org
Amygdaloid circuits are involved in a variety of emotional and motivation-related behaviors
and are impacted by stress. The amygdala expresses several neuromodulatory systems …

Alternating sources of perisomatic inhibition during behavior

B Dudok, PM Klein, E Hwaun, BR Lee, Z Yao, O Fong… - Neuron, 2021 - cell.com
Interneurons expressing cholecystokinin (CCK) and parvalbumin (PV) constitute two key
GABAergic controllers of hippocampal pyramidal cell output. Although the temporally …

Early life adversity decreases pre-adolescent fear expression by accelerating amygdala PV cell development

G Manzano Nieves, M Bravo, S Baskoylu, KG Bath - Elife, 2020 - elifesciences.org
Early life adversity (ELA) is associated with increased risk for stress-related disorders later in
life. The link between ELA and risk for psychopathology is well established but the …

Anatomical and molecular characterization of parvalbumin-cholecystokinin co-expressing inhibitory interneurons: implications for neuropsychiatric conditions

SF Grieco, KG Johnston, P Gao, BM Garduño… - Molecular …, 2023 - nature.com
Inhibitory interneurons are crucial to brain function and their dysfunction is implicated in
neuropsychiatric conditions. Emerging evidence indicates that cholecystokinin (CCK) …

Total number and ratio of GABAergic neuron types in the mouse lateral and basal amygdala

VK Vereczki, K Müller, É Krizsán, Z Máté… - Journal of …, 2021 - Soc Neuroscience
GABAergic neurons are key circuit elements in cortical networks. Despite growing evidence
showing that inhibitory cells play a critical role in the lateral (LA) and basal (BA) amygdala …

The endocannabinoid system in the amygdala and modulation of fear

O Gunduz-Cinar - Progress in Neuro-Psychopharmacology and …, 2021 - Elsevier
Posttraumatic stress disorder (PTSD) is a persistent, trauma induced psychiatric condition
characterized by lifelong complex cognitive, emotional and behavioral phenotype. Although …

[HTML][HTML] Maturation of amygdala inputs regulate shifts in social and fear behaviors: a substrate for developmental effects of stress

NC Ferrara, S Trask, JA Rosenkranz - Neuroscience & Biobehavioral …, 2021 - Elsevier
Stress can negatively impact brain function and behaviors across the lifespan. However,
stressors during adolescence have particularly harmful effects on brain maturation, and on …

Effects of optogenetic photoexcitation of infralimbic cortex inputs to the basolateral amygdala on conditioned fear and extinction

O Bukalo, M Nonaka, CA Weinholtz, A Mendez… - Behavioural brain …, 2021 - Elsevier
Deficiencies in the ability to extinguish fear is a hallmark of Trauma-and stressor-related
disorders, Anxiety disorders, and certain other neuropsychiatric conditions. Hence, a greater …