Insulin signalling in the central nervous system regulates energy homeostasis by controlling
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …

The liver is an essential metabolic organ, and its metabolic activity is tightly controlled by
insulin and other metabolic hormones. Glucose is metabolized into pyruvate through …

During insulin-resistant states such as type 2 diabetes mellitus (T2DM), insulin fails to
suppress hepatic glucose production but promotes lipid synthesis leading to hyperglycemia …

Glucose metabolism is normally regulated by a feedback loop including islet β cells and
insulin-sensitive tissues, in which tissue sensitivity to insulin affects magnitude of β-cell …

Insulin resistance is associated with numerous metabolic disorders, such as obesity and
type II diabetes, that currently plague our society. Although insulin normally promotes …

Accumulated evidence from genetic animal models suggests that the brain, particularly the
hypothalamus, has a key role in the homeostatic regulation of energy and glucose …

The vagus nerve has an important role in regulation of metabolic homeostasis, and efferent
vagus nerve-mediated cholinergic signalling controls immune function and proinflammatory …

Polyphenols, including flavonoids, phenolic acids, proanthocyanidins and resveratrol, are a
large and heterogeneous group of phytochemicals in plant-based foods, such as tea, coffee …

During insulin-resistant states such as type II diabetes mellitus (T2DM), insulin fails to
suppress hepatic glucose production (HGP) yet promotes lipid synthesis. This metabolic …

Adipocytes store excess energy in the form of triglycerides and signal the levels of stored
energy to the brain. Here we show that adipocyte-specific deletion of Arntl (also known as …