Lysosomes were once considered the end point of endocytosis, simply used for
macromolecule degradation. They are now recognized to be dynamic organelles, able to …

Summary β-Coronaviruses are a family of positive-strand enveloped RNA viruses that
includes the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Much is …

Retrograde transport from endosomes to the trans-Golgi network is essential for recycling of
protein and lipid cargoes to counterbalance anterograde membrane traffic. Protein cargo …

Amyloid beta peptide (Aβ), the main component of senile plaques of Alzheimer's disease
brains, is produced by sequential cleavage of amyloid precursor protein (APP) and of its C …

MicroRNAs (miRNAs) are released from cells in association with proteins or microvesicles.
We previously reported that malignant transformation changes the assortment of released …

Loss-of-function mutations in endosomal Na+/H+ exchanger 6 (NHE6) cause the X-linked
neurologic disorder Christianson syndrome. Patients exhibit symptoms associated with both …

Huntington9s disease (HD) is an autosomal-dominant neurodegenerative disorder caused
by the expansion of a CAG triplet in the gene encoding for huntingtin (Htt). The resulting …

Recent studies have demonstrated that human tau can be secreted by neurons and non-
neuronal cells, an event linked to the propagation of tau pathology in the brain. In the …

Wiskott-Aldrich syndrome protein and SCAR homologue (WASH) is an important regulator of
vesicle trafficking. By generating actin on the surface of intracellular vesicles, WASH is able …

Summary Weibel–Palade bodies (WPBs) are endothelial-cell-specific organelles that, upon
fusion with the plasma membrane, release cargo molecules that are essential in blood …