Reprogramming of cardiac phosphoproteome, proteome, and transcriptome confers resilience to chronic adenylyl cyclase-driven stress
JH Qu, K Chakir, KV Tarasov, DR Riordon, MG Perino… - Elife, 2024 - elifesciences.org
Our prior study (Tarasov et al., 2022) discovered that numerous adaptive mechanisms
emerge in response to cardiac-specific overexpression of adenylyl cyclase type 8 (TGAC8) …
emerge in response to cardiac-specific overexpression of adenylyl cyclase type 8 (TGAC8) …
Enhanced myocardial adenylyl cyclase activity alters heart-brain communication
Background The central nervous system's influence on cardiac function is well described;
however, direct evidence for signaling from heart to brain remains sparse. Mice with cardiac …
however, direct evidence for signaling from heart to brain remains sparse. Mice with cardiac …
[PDF][PDF] Cardiac AC8 Over-Expression Increases Locomotion by Altering Heart-Brain Communication
ABSTRACT BACKGROUND The central nervous system's influence on cardiac function is
well described; however, direct evidence for signaling from heart to brain remains sparse …
well described; however, direct evidence for signaling from heart to brain remains sparse …
[HTML][HTML] Characterization of diverse populations of sinoatrial node cells and their proliferation potential at single nucleus resolution
JH Qu, R Telljohann, R Byshkov, EG Lakatta - Heliyon, 2023 - cell.com
Background Each heartbeat is initiated in the sinoatrial node (SAN), and although a recent
study (GSE130710) using single nucleus RNA-seq had discovered different populations of …
study (GSE130710) using single nucleus RNA-seq had discovered different populations of …
The reprogrammed mouse heart phosphoproteome in response to the chronic stress of markedly high cardiac-specific adenylyl cyclase type 8 overexpression
JH Qu, K Chakir, KV Tarasov, DR Riordon, MG Perino… - bioRxiv, 2022 - biorxiv.org
An appropriate intensity and duration of increased AC-cAMP-PKA-Ca2+ signaling is the
quintessential component of acute adaptation to cardiac stress. Our previous work …
quintessential component of acute adaptation to cardiac stress. Our previous work …
[HTML][HTML] Reprogramming of the cardiac phosphoproteome in conjunction with proteome and transcriptome creates the enhanced performance and protection circuitry …
JH Qu, K Chakir, KV Tarasov, DR Riordon, MG Perino… - eLife, 2023 - elifesciences.org
Our previous work demonstrated the existence of a remarkable adaptive paradigm of heart
performance and protection in response to the constitutive challenge of marked cardiac …
performance and protection in response to the constitutive challenge of marked cardiac …
A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs …
NM Winicki, AP Nanavati, CH Morrell… - Frontiers in …, 2023 - frontiersin.org
Background Aging is associated with increased levels of reactive oxygen species and
inflammation that disrupt proteostasis and mitochondrial function and leads to organism …
inflammation that disrupt proteostasis and mitochondrial function and leads to organism …
Cardiac-specific overexpression of adenylyl cyclase 8 reprograms the mouse sinoatrial node transcriptome
JH Qu, KV Tarasov, K Chakir, EG Lakatta - Biophysical Journal, 2024 - cell.com
Tuesday, February 13, 2024 385a differed in TGAC8 vs. WT, the top three being OXPHOS,
ribosome, and cardiac muscle contraction. In contrast, signaling pathways related to inositol …
ribosome, and cardiac muscle contraction. In contrast, signaling pathways related to inositol …
Cardiomyocyte adenyl cyclase 8 overexpression increases locomotor activity in mice by modulating EEG-gamma oscillations
The central nervous system modulates heart function on a beat-to-beat basis via
increasingly understood mechanisms. Conversely, whether and how humoral/functional …
increasingly understood mechanisms. Conversely, whether and how humoral/functional …