Genetic causes and modifiers of autism spectrum disorder

L Rylaarsdam, A Guemez-Gamboa - Frontiers in cellular …, 2019 - frontiersin.org
Autism Spectrum Disorder (ASD) is one of the most prevalent neurodevelopmental
disorders, affecting an estimated 1 in 59 children. ASD is highly genetically heterogeneous …

The genetics of autism

R Muhle, SV Trentacoste, I Rapin - Pediatrics, 2004 - publications.aap.org
Autism is a complex, behaviorally defined, static disorder of the immature brain that is of
great concern to the practicing pediatrician because of an astonishing 556% reported …

Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations

MG Butler, MJ Dasouki, XP Zhou… - Journal of medical …, 2005 - jmg.bmj.com
The genetic aetiology of autism remains elusive. Occasionally, individuals with Cowden
syndrome (a cancer syndrome) and other related hamartoma disorders such as Bannayan …

The genetics of autistic disorders and its clinical relevance: a review of the literature

CM Freitag - Molecular psychiatry, 2007 - nature.com
Twin and family studies in autistic disorders (AD) have elucidated a high heritability of the
narrow and broad phenotype of AD. In this review on the genetics of AD, we will initially …

[HTML][HTML] Autismo e doenças invasivas de desenvolvimento

CA Gadia, R Tuchman, NT Rotta - Jornal de pediatria, 2004 - SciELO Brasil
OBJETIVO: Revisar os aspectos neurobiológicos do autismo e das doenças invasivas de
desenvolvimento. Oferecer ao pediatra informações atualizadas sobre diagnóstico e …

What is known about autism: genes, brain, and behavior

SL Santangelo, K Tsatsanis - American Journal of Pharmacogenomics, 2005 - Springer
Autism is a neurodevelopmental disorder of genetic origins, with a heritability of about 90%.
Autistic disorder is classed within the broad domain of pervasive developmental disorders …

Oligogenic heterozygosity in individuals with high-functioning autism spectrum disorders

CP Schaaf, A Sabo, Y Sakai, J Crosby… - Human molecular …, 2011 - academic.oup.com
Autism spectrum disorders (ASDs) are a heterogeneous group of neuro-developmental
disorders. While significant progress has been made in the identification of genes and copy …

Animal models relevant to schizophrenia and autism: validity and limitations

S Tordjman, D Drapier, O Bonnot, R Graignic, S Fortes… - Behavior genetics, 2007 - Springer
Abstract Development of animal models is a crucial issue in biological psychiatry. Animal
models provide the opportunity to decipher the relationships between the nervous system …

Macrocephaly and the control of brain growth in autistic disorders

P McCaffery, CK Deutsch - Progress in neurobiology, 2005 - Elsevier
Autism is a childhood-onset neuropsychiatric disorder characterized by marked impairments
in social interactions and communication, with restricted stereotypic and repetitive patterns …

A review of gene linkage, association and expression studies in autism and an assessment of convergent evidence

MS Yang, M Gill - International Journal of Developmental Neuroscience, 2007 - Elsevier
Autism is a neurodevelopmental disorder with high heritability and a likely complex genetic
architecture. Much genetic evidence has accumulated in the last 20 years but no gene has …