Circadian regulation of drug responses: toward sex-specific and personalized chronotherapy
Today's challenge for precision medicine involves the integration of the impact of molecular
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …
Circadian rhythm and disease: Relationship, new insights, and future perspectives
AR Neves, T Albuquerque, T Quintela… - Journal of cellular …, 2022 - Wiley Online Library
The circadian system is responsible for internal functions and regulation of the organism
according to environmental cues (zeitgebers). Circadian rhythm dysregulation or …
according to environmental cues (zeitgebers). Circadian rhythm dysregulation or …
Circadian biology to advance therapeutics for mood disorders
Mood disorders account for a significant global disease burden, and pharmacological
innovation is needed as existing medications are suboptimal. A wide range of evidence …
innovation is needed as existing medications are suboptimal. A wide range of evidence …
Circadian dysfunction in adipose tissue: chronotherapy in metabolic diseases
Simple Summary The circadian timing system is our bodies' built-in clock and controls our
physiology on a daily basis. This system helps us adapt to changes in our environment, such …
physiology on a daily basis. This system helps us adapt to changes in our environment, such …
[HTML][HTML] Interactions of circadian clock genes with the hallmarks of cancer
SM Ortega-Campos, EM Verdugo-Sivianes… - … et Biophysica Acta (BBA …, 2023 - Elsevier
The molecular machinery of the circadian clock regulates the expression of many genes and
processes in the organism, allowing the adaptation of cellular activities to the daily light-dark …
processes in the organism, allowing the adaptation of cellular activities to the daily light-dark …
Identification of novel small molecules targeting core clock proteins to regulate circadian rhythm
The circadian rhythms are physiological, biochemical, and behavioral oscillations that cycle
every 24 hours to anticipate the daily changes in the external environment. Disruption of the …
every 24 hours to anticipate the daily changes in the external environment. Disruption of the …
Single nucleotide polymorphisms (SNPs) in circadian genes: Impact on gene function and phenotype
I Baris, O Ozcan, IH Kavakli - Advances in protein chemistry and structural …, 2023 - Elsevier
Circadian rhythm is an endogenous timing system that allows an organism to anticipate and
adapt to daily changes and regulate various physiological variables such as the sleep-wake …
adapt to daily changes and regulate various physiological variables such as the sleep-wake …
The secondary pocket of cryptochrome 2 is important for the regulation of its stability and localization
Human clock-gene variations contribute to the phenotypic differences observed in various
behavioral and physiological processes, such as diurnal preference, sleep, metabolism …
behavioral and physiological processes, such as diurnal preference, sleep, metabolism …
Why does circadian timing of administration matter for immune checkpoint inhibitors' efficacy?
A Karaboué, PF Innominato, NI Wreglesworth… - British Journal of …, 2024 - nature.com
Background Tolerability and antitumour efficacy of chemotherapy and radiation therapy can
vary largely according to their time of administration along the 24-h time scale, due to the …
vary largely according to their time of administration along the 24-h time scale, due to the …
Dynamic regulation of the serine loop by distant mutations reveals allostery in cryptochrome1
O Ozcan, S Gul, IH Kavakli - Journal of Biomolecular Structure and …, 2024 - Taylor & Francis
Cryptochromes (CRYs) are essential components of the molecular clock that generates
circadian rhythm. They inhibit BMAL1/CLOCK-driven transcription at the molecular level …
circadian rhythm. They inhibit BMAL1/CLOCK-driven transcription at the molecular level …