Near-infrared (NIR) spectroscopy occupies a specific spot across the field of bioscience and
related disciplines. Its characteristics and application potential differs from infrared (IR) or …

One of the major aims of bioprocess engineering is the real-time monitoring of important
process variables. This is the basis of precise process control and is essential for high …

Expansion of umbilical cord blood mononuclear cells (UCB MNCs) was carried out in a
rotating wall vessel (RWV) bioreactor and tissue culture flasks (T-flasks) in serum-containing …

Background Analysis of the glutamine metabolic pathway has taken a special place in
metabolomics research in recent years, given its important role in cell biosynthesis and …

Quality by Design (QbD) for biotechnology-related pharmaceuticals Page 1 HAL Id: hal-00480831
https://hal.science/hal-00480831 Submitted on 5 May 2010 HAL is a multi-disciplinary open …

Metastatic seeding leads to most of the morbidity from carcinomas. However, little is known
of this key event as current methods to study the cellular behaviors utilize nonrepresentative …

The need for successful ex-vivo expansion and directed differentiation of haematopoietic
stem cells (HSCs) for therapeutic applications has increased over the past decade …

The biopharmaceutical industry must guarantee the efficiency and biosafety of biological
medicines, which are quite sensitive to cell culture process variability. Real‐time monitoring …

During the last years, non-invasive or minimally invasive diagnostic tools in cancer
diagnostics have become more important. Many fluorescence spectroscopic methodologies …

Animal cell culture processes have become the standard platform to produce therapeutic
proteins such as recombinant monoclonal antibodies (mAb). Since the mAb quality could be …