[HTML][HTML] Receptor-arrestin interactions: the GPCR perspective
M Seyedabadi, M Gharghabi, EV Gurevich… - Biomolecules, 2021 - mdpi.com
Arrestins are a small family of four proteins in most vertebrates that bind hundreds of
different G protein-coupled receptors (GPCRs). Arrestin binding to a GPCR has at least three …
different G protein-coupled receptors (GPCRs). Arrestin binding to a GPCR has at least three …
[HTML][HTML] G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders
Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …
Identifying treatment targets is challenging because the diseases are resulting from …
[HTML][HTML] GPCRome-wide analysis of G-protein-coupling diversity using a computational biology approach
GPCRs are master regulators of cell signaling by transducing extracellular stimuli into the
cell via selective coupling to intracellular G-proteins. Here we present a computational …
cell via selective coupling to intracellular G-proteins. Here we present a computational …
[HTML][HTML] Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor
Cholecystokinin A receptor (CCKAR) belongs to family A G-protein-coupled receptors and
regulates nutrient homeostasis upon stimulation by cholecystokinin (CCK). It is an attractive …
regulates nutrient homeostasis upon stimulation by cholecystokinin (CCK). It is an attractive …
[HTML][HTML] Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84
GPR84 is an orphan class AG protein-coupled receptor (GPCR) that is predominantly
expressed in immune cells and plays important roles in inflammation, fibrosis, and …
expressed in immune cells and plays important roles in inflammation, fibrosis, and …
Cryo-EM structure of an activated GPCR–G protein complex in lipid nanodiscs
G-protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane
proteins and the targets of over 30% of currently marketed pharmaceuticals. Although …
proteins and the targets of over 30% of currently marketed pharmaceuticals. Although …
[HTML][HTML] Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
Peptide hormones and neuropeptides are complex signaling molecules that predominately
function through G protein-coupled receptors (GPCRs). Two unanswered questions …
function through G protein-coupled receptors (GPCRs). Two unanswered questions …
[HTML][HTML] Structure, function and drug discovery of GPCR signaling
L Cheng, F Xia, Z Li, C Shen, Z Yang, H Hou… - Molecular …, 2023 - Springer
G protein-coupled receptors (GPCRs) are versatile and vital proteins involved in a wide
array of physiological processes and responses, such as sensory perception (eg, vision …
array of physiological processes and responses, such as sensory perception (eg, vision …
Structural insights into ligand recognition, activation, and signaling of the α2A adrenergic receptor
The α2A adrenergic receptor (α2AAR) is a G protein (heterotrimeric guanine nucleotide–
binding protein)–coupled receptor that mediates important physiological functions in …
binding protein)–coupled receptor that mediates important physiological functions in …
[HTML][HTML] Structural insights into the G protein selectivity revealed by the human EP3-Gi signaling complex
Prostaglandin receptors have been implicated in a wide range of functions, including
inflammation, immune response, reproduction, and cancer. Our group has previously …
inflammation, immune response, reproduction, and cancer. Our group has previously …