Cancer cell extravasation, a key step in the metastatic cascade, involves cancer cell arrest
on the endothelium, transendothelial migration (TEM), followed by the invasion into the …

Abstract Development of three dimensional (3D) in vitro models to realistically recapitulate
tumor microenvironment has the potential to improve translatability of anti-cancer drugs at …

The human thymus is the site of T‐cell maturation and induction of central tolerance.
Hematopoietic stem cell (HSC)‐derived progenitors are recruited to the thymus from the fetal …

Blood-brain barrier (BBB) dysfunction plays a pivotal role in the pathology of chronic
cerebral hypoperfusion (CCH)-related neurodegenerative diseases. Continuous endothelial …

Topologically associated domains (TADs) restrict promoter-enhancer interactions, thereby
maintaining the spatiotemporal pattern of gene activity. However, rearrangements of the …

Transcriptomic data can be mined to understand the molecular activity of cell types. Yet,
functional genes may remain undetected in RNA sequencing (RNA-seq) experiments for …

Vascularization is driven by morphogen signals and mechanical cues that coordinately
regulate cellular force generation, migration, and shape change to sculpt the developing …