Severe COVID-19, multisystem inflammatory syndrome in children, and Kawasaki disease: immunological mechanisms, clinical manifestations and management

J Kabeerdoss, RK Pilania, R Karkhele… - Rheumatology …, 2021 - Springer
Multisystem inflammatory syndrome (MIS-C) is a pediatric hyperinflammation disorder
caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). It has now been …

A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity

AT Huang, B Garcia-Carreras, MDT Hitchings… - Nature …, 2020 - nature.com
Many public health responses and modeled scenarios for COVID-19 outbreaks caused by
SARS-CoV-2 assume that infection results in an immune response that protects individuals …

[HTML][HTML] Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection

EM Anderson, EC Goodwin, A Verma, CP Arevalo… - Cell, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread within
the human population. Although SARS-CoV-2 is a novel coronavirus, most humans had …

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

KW Ng, N Faulkner, GH Cornish, A Rosa, R Harvey… - Science, 2020 - science.org
Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in
humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we …

Seasonal coronavirus protective immunity is short-lasting

AWD Edridge, J Kaczorowska, ACR Hoste, M Bakker… - Nature medicine, 2020 - nature.com
A key unsolved question in the current coronavirus disease 2019 (COVID-19) pandemic is
the duration of acquired immunity. Insights from infections with the four seasonal human …

COVID-19: Immunology and treatment options

S Felsenstein, JA Herbert, PS McNamara… - Clinical …, 2020 - Elsevier
The novel coronavirus SARS-CoV2 causes COVID-19, a pandemic threatening millions. As
protective immunity does not exist in humans and the virus is capable of escaping innate …

SARS-CoV-2 S2–targeted vaccination elicits broadly neutralizing antibodies

KW Ng, N Faulkner, K Finsterbusch, M Wu… - Science translational …, 2022 - science.org
Several variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have
emerged during the current coronavirus disease 2019 (COVID-19) pandemic. Although …

The dynamics of humoral immune responses following SARS-CoV-2 infection and the potential for reinfection

P Kellam, W Barclay - Journal of General Virology, 2020 - microbiologyresearch.org
SARS-CoV-2 is a novel coronavirus that is the causative agent of coronavirus infectious
disease 2019 (COVID-19). As of 17 April 2020, it has infected 2 114 269 people, resulting in …

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

AJ Brown, JJ Won, RL Graham, KH Dinnon III, AC Sims… - Antiviral research, 2019 - Elsevier
Abstract The genetically diverse Orthocoronavirinae (CoV) family is prone to cross species
transmission and disease emergence in both humans and livestock. Viruses similar to …

Hosts and sources of endemic human coronaviruses

VM Corman, D Muth, D Niemeyer, C Drosten - Advances in virus research, 2018 - Elsevier
The four endemic human coronaviruses HCoV-229E,-NL63,-OC43, and-HKU1 contribute a
considerable share of upper and lower respiratory tract infections in adults and children …