Alkaloids from plants are characterised by structural diversity and bioactivity, and maintain a
privileged position in both modern and traditional medicines. In recent years, there have …

Vinblastine, a potent anticancer drug, is produced by Catharanthus roseus (Madagascar
periwinkle) in small quantities, and heterologous reconstitution of vinblastine biosynthesis …

Huperzine A (HupA) is a plant-derived lycopodium alkaloid used for the treatment of
Alzheimer's disease due to its inhibition against acetylcholinesterase. Currently, industrial …

Monoterpene indole alkaloids comprise a diverse family of over 2000 plant-produced
natural products. This pathway provides an outstanding example of how nature creates …

Olive (Olea europaea) is a rich source of valuable bioactive polyphenols, which has
attracted widespread interest. In this study, we combined targeted metabolome, Pacbio …

Plants have always been used as medicines since ancient times to treat diseases. The
knowledge around the active components of herbal preparations has remained …

Catharanthus roseus leaves produce a range of monoterpenoid indole alkaloids (MIAs) that
include low levels of the anticancer drugs vinblastine and vincristine. The MIA pathway …

The large family of cytochrome P450 enzymes are heme containing proteins generally
associated with the cytoplasmic face of the endoplasmic reticulum in Eukaryotic cells. They …

Plants use monoterpenols as precursors for the production of functionally and structurally
diverse molecules, which are key players in interactions with other organisms such as …

Swertia mussotii Franch. is an important traditional Tibetan medicinal plant with
pharmacological properties effective in the treatment of various ailments including hepatitis …