In the history of therapeutics, covalent drugs occupy a very distinct category. While
representing a significant fraction of the drugs on the market, very few have been …

Using high-throughput microfluidic enzyme kinetics (HT-MEK), we measured over 9,000
inhibition curves detailing impacts of 1,004 single-site mutations throughout the alkaline …

Supramolecular structure and properties of deep eutectic solvents (DESs) are known to be
highly affected by the addition of water, and their use as solvents for poorly water-soluble …

Lysozyme is an important component of the host innate defense system. It cleaves the β-1, 4
glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine of bacterial …

Abnormal glycosylation is a common feature in disease that typically results from
misregulation in expression and/or activity of glycosyltransferases (GTs) and glycosidases …

We investigated the dissociation process of tri-N-acetyl-d-glucosamine from hen egg white
lysozyme using parallel cascade selection molecular dynamics (PaCS-MD), which …

Endolysins are peptidoglycan-degrading enzymes utilized by bacteriophages to release the
progeny from bacterial cells. The lytic properties of phage endolysins make them potential …

Phage lysins are a source of novel antimicrobials to tackle the bacterial antibiotic-resistance
crisis. The engineering of phage lysins is being explored as a game-changing technological …

Lysozyme hydrolyzes the glycosidic bonds between N-acetylmuramic acid and N-
acetylglucosamine in peptidoglycans located in the bacterial cell wall. The mechanism of the …

Bacteria express lytic enzymes such as glycosidases, which have potentially self‐destructive
peptidoglycan (PG)‐degrading activity and, therefore, require careful regulation in bacteria …