The pathology of X-linked adrenoleukodystrophy: tissue specific changes as a clue to pathophysiology
HAF Yska, M Engelen, M Bugiani - Orphanet Journal of Rare Diseases, 2024 - Springer
Although the pathology of X-linked adrenoleukodystrophy (ALD) is well described, it
represents the end-stage of neurodegeneration. It is still unclear what cell types are initially …
represents the end-stage of neurodegeneration. It is still unclear what cell types are initially …
Efficacy of HDAC Inhibitors in Driving Peroxisomal β-Oxidation and Immune Responses in Human Macrophages: Implications for Neuroinflammatory Disorders
A Villoria-González, B Zierfuss, P Parzer, E Heuböck… - Biomolecules, 2023 - mdpi.com
Elevated levels of saturated very long-chain fatty acids (VLCFAs) in cell membranes and
secreted lipoparticles have been associated with neurotoxicity and, therefore, require tight …
secreted lipoparticles have been associated with neurotoxicity and, therefore, require tight …
Peroxisomal Localization of a Truncated HMG-CoA Reductase under Low Cholesterol Conditions
J Wang, M Kunze, A Villoria-González, I Weinhofer… - Biomolecules, 2024 - mdpi.com
3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase, HMGCR) is one of the rate-
limiting enzymes in the mevalonate pathway required for cholesterol biosynthesis. It is an …
limiting enzymes in the mevalonate pathway required for cholesterol biosynthesis. It is an …