Leptin is a hormone primarily produced by the adipose tissue in proportion to the size of fat
stores, with a primary function in the control of lipid reserves. Besides adipose tissue, leptin …

The global obesity epidemic is a major contributor to chronic disease and disability in the
world today. Since the discovery of leptin in 1994, a multitude of studies have characterized …

Leptin promotes satiety and modulates energy balance and weight. Diet-induced obesity
leads to leptin resistance, exacerbating overeating. We reviewed the literature on the …

Obesity is a chronic disease that represents one of the most serious global health burdens
associated to an excess of body fat resulting from an imbalance between energy intake and …

The worldwide prevalence of metabolic diseases such as obesity, metabolic syndrome and
type 2 diabetes shows an upward trend in recent decades. A characteristic feature of these …

Adipose tissue plays a central role in regulating whole-body energy and glucose
homeostasis through its subtle functions at both organ and systemic levels. On one hand …

The assimilation, storage and use of energy from nutrients constitute a homeostatic system
that is essential for life. In vertebrates, the ability to store sufficient quantities of energy-dense …

The recently discovered orexigenic peptide ghrelin is produced primarily by the stomach
and circulates in blood at levels that increase during prolonged fasting in rats. When …

Absorption of monosaccharides is mainly mediated by Na+-d-glucose cotransporter SGLT1
and the facititative transporters GLUT2 and GLUT5. SGLT1 and GLUT2 are relevant for …

Leptin and ghrelin are two hormones that have been recognized to have a major influence
on energy balance. Leptin is a mediator of long‐term regulation of energy balance …