The outcome of Mycobacterium tuberculosis (Mtb) infection ranges from a complete
pathogen clearance through asymptomatic latent infection (LTBI) to active tuberculosis (TB) …

Objectives New tests are needed to overcome the limitations of existing immunodiagnostic
tests for tuberculosis (TB) infection, including their inability to differentiate between active TB …

Background Mycobacterium tuberculosis antigen (Mtb-Ag) is a polypeptide component with
a molecular weight of 10-14 kDa that is obtained from the supernatant of the H37Ra strain …

Objective Accurate and timely diagnosis of tuberculosis (TB) is essential to control the global
pandemic. Currently available immunodiagnostic tests cannot discriminate between latent …

Objectives Currently available interferon (IFN)-γ-release assays (IGRA) cannot discriminate
active tuberculosis (TB) from latent TB infection (LTBI), and so have limited clinical utility for …

Objectives The IFN-γ-release assay (IGRA) cannot differentiate active tuberculosis (TB) from
latent TB infection (LTBI). We hypothesized that the TNF-α-release assay (TARA) combined …

Human studies have identified the potential of measuring Mycobacterium tuberculosis
specific IFN-γ and/or IL-2 secreting T cell subsets to distinguish different clinical stages of …

Currently available Interferon-γ release assay (IGRA) cannot reliably differentiate active TB
(ATB) from non-active TB (non-ATB). A study was performed to evaluate the value of …

End-stage renal disease (ESRD) patients exhibit elevated risk of tuberculosis (TB)
reactivation, but current diagnostics, including the interferon gamma release assay (IGRA) …

В монографии обобщены современные данные об особенностях иммунного ответа
при туберкулезной инфекции, а также роли цитокинов в иммунопатогенезе …